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cardioresp drugs > asthma > Flashcards

asthma Flashcards

1
Q

SABA examples

A

Terbutaline

salbutamol

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2
Q

salbutamol target

A

B2 receptors

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3
Q

where is salbutamol target

A

smooth muscle

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4
Q

effect of salbutamol binding to receptors

A

increases adenylate cyclase and then CAMP

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5
Q

common side effects of salbutamol

A

Fine tremor; Headache; Muscle cramps; Palpitations

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6
Q

bad side effects of salbutamol

A

Arrhythmias
Myocardial ischaemia
Hypokalaemia (high doses)
Lactic acidosis (high doses)

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7
Q

LAMA

A

tiotropium

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8
Q

SAMA

A

ipratropium

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9
Q

tiotropium target

A

M3

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10
Q

tiotropium moa

A

competes with acetylcholine = no constriction

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11
Q

when would you use tiotropium

A

COPD

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12
Q

drug interactions with tiotropium

A

unlikely

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13
Q

tiotropium common side effects

A

Dry mouth; Nausea; Headache; constipation; cough

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14
Q

tiotropium bad side effects

A

Atrial fibrillation
Acute angle closure glaucoma
Urinary retention

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15
Q

montelukast

A

Leukotriene receptor antagonists

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16
Q

montelukast target

A

Cysteinyl leukotriene receptor CysLT1

17
Q

montelukast overall effect

A

reduce the inflammation in asthma and rhinitis

excersize or asthma induced

18
Q

montelukast common side effects

A

GI
thirst
headache

19
Q

montelukast important side effects

A

Churg-Strauss syndrome
Hypersensitivity (including anaphylaxis and angioedema)
Depression, suicidal thoughts and behaviour
Seizures

20
Q

what asthma drug may cause agranulocytosis

A

zafirklukast

21
Q

what is churg strauss

A

systemic necrotizing vasculitis

22
Q

LABA

A

formeterol

salmeterol

23
Q

theophylline drug class

A

phosphodiesterase inhibitor

24
Q

what does phosphidiesterase do

A

enzyme responsible for breaking down cyclic AMP in smooth muscle cells

25
Q

additional thing theophylline binds to

A

adenosine A2B receptor

26
Q

how does Sodium cromoglicate work

A

inhibiting the release of chemical mediators from sensitized mast cells

27
Q

what asthma situation does Sodium cromoglicate not work

A

asthma attack

cardioresp drugs (13 decks)

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