asthma Flashcards
SABA examples
Terbutaline
salbutamol
salbutamol target
B2 receptors
where is salbutamol target
smooth muscle
effect of salbutamol binding to receptors
increases adenylate cyclase and then CAMP
common side effects of salbutamol
Fine tremor; Headache; Muscle cramps; Palpitations
bad side effects of salbutamol
Arrhythmias
Myocardial ischaemia
Hypokalaemia (high doses)
Lactic acidosis (high doses)
LAMA
tiotropium
SAMA
ipratropium
tiotropium target
M3
tiotropium moa
competes with acetylcholine = no constriction
when would you use tiotropium
COPD
drug interactions with tiotropium
unlikely
tiotropium common side effects
Dry mouth; Nausea; Headache; constipation; cough
tiotropium bad side effects
Atrial fibrillation
Acute angle closure glaucoma
Urinary retention
montelukast
Leukotriene receptor antagonists
montelukast target
Cysteinyl leukotriene receptor CysLT1
montelukast overall effect
reduce the inflammation in asthma and rhinitis
excersize or asthma induced
montelukast common side effects
GI
thirst
headache
montelukast important side effects
Churg-Strauss syndrome
Hypersensitivity (including anaphylaxis and angioedema)
Depression, suicidal thoughts and behaviour
Seizures
what asthma drug may cause agranulocytosis
zafirklukast
what is churg strauss
systemic necrotizing vasculitis
LABA
formeterol
salmeterol
theophylline drug class
phosphodiesterase inhibitor
what does phosphidiesterase do
enzyme responsible for breaking down cyclic AMP in smooth muscle cells
additional thing theophylline binds to
adenosine A2B receptor
how does Sodium cromoglicate work
inhibiting the release of chemical mediators from sensitized mast cells
what asthma situation does Sodium cromoglicate not work
asthma attack
