TB Flashcards
what are the TB drugs
Isoniazid
Rifampicin
Pyrazinamide
Ethambutol
isoniazid drug class
mycolic acid synthesis inhibitor
isoniazid affect on rapid/slow dividing bacteria
kills rapid
static slow
how is isoniazid activated
bacteria catalase
rifampacin drug class
RNA/DNA polymerase inhibitor
what is mycolic acid
important part of the cell wall
rifampacin spec
broad
rifampacin good aspect
only targets DNA version of the polymerase
rifampacin metabolised where
liver
how is rifampacin eliminated
bile
Pyrazinamide requirement to work
slightly acidic
ways in which Pyrazinamide works
Interfere with fatty acid synthase (FAS I)
Disrupt membrane potential and energy production,
Bind to the ribosomal protein S1 and inhibit trans-translation
Pyrazinamide special thing
can work against dormant TB
how does ethambutol work
inhibit arabinosyl transferases
