pneumonia antimicrobial

Question 1

Clarithromycin drug class

Answer 1

Macrolide antibiotics

Question 2

Clarithromycin target

Answer 2

50s subunit of bacterial ribosome

Question 3

Clarithromycin moa

Answer 3

Prevent transfer of bacterial tRNA from A-site to P-site on the ribosome, thus preventing elongation of the polypeptide chain

Question 4

Clarithromycin aim

Answer 4

inhibit bacterial protein synthesis

Question 5

Clarithromycin bad side effects

Answer 5

QT interval prolongation, arrhythmias
Hepatotoxicity
Stevens-Johnson syndrome, toxic epidermal necrolysis

Question 6

Clarithromycin common side effect

Answer 6

taste change

Question 7

Doxycycline class

Answer 7

tetracycline

Question 8

Doxycycline target

Answer 8

Bacterial 30s ribosomal subunit

Question 9

Doxycycline moa

Answer 9

Reversibly binds to the 30s ribosomal subunit blocking tRNA binding

Question 10

Doxycycline common adverse effect

Answer 10

dysphagia

Question 11

Doxycycline advice

Answer 11

high factor sunscreen

Question 12

bad side effect Doxycycline

Answer 12

tooth staining

blood disorder

Question 13

Cefuroxime drug class

Answer 13

β-lactam antibiotics – Cephalosporins

Question 14

Cefuroxime moa

Answer 14

Inhibit cross-linking of NAMA/NAG peptide chains in the peptidoglycan bacterial cell wall

Question 15

Cefuroxime target

Answer 15

Bacterial penicillin-binding proteins/transpeptidase enzymes

Question 16

Cefuroxime bad side effects

Answer 16

Hypersensitivity
Antibiotic-associated diarrhoea/colitis
Cholestatic jaundice (ceftriaxone)
Stevens-Johnson syndrome, toxic epidermal necrolysis