Hyperlipidaemia and cardiovascular risk reduction

Question 1

Simvastatin drug class

Answer 1

HMG Co-enzyme A reductase inhibitors

Question 2

Simvastatin moa

Answer 2

reduces hepatic cholesterol synthesis through the mevalonate pathway

Question 3

Simvastatin knock on effect

Answer 3

upregulation of the LDL-receptors and increased hepatic removal of LDL from the circulation

Question 4

Simvastatin important adverse effects

Answer 4

Myalgia

Myositis, rhabdomyolysis

Question 5

atorvastatin drug class

Answer 5

HMG-CoA reductase inhibitor

Question 6

atorvastatin half life

Answer 6

long

Question 7

atorvastatin good thing over other statins

Answer 7

hepatic selectivity

Question 8

what does HMG-CoA reductase do

Answer 8

converts HMG-CoA to mevalonate

Question 9

Bezafibrate drug class

Answer 9

antilipemic agent

Question 10

how does bezafibrate work

Answer 10

activation of triglyceride lipases

Question 11

Bezafibrate agonises

Answer 11

PPARα

Question 12

Ezetimibe lowers

Answer 12

cholesterol

Question 13

Ezetimibe moa

Answer 13

selectively blocks the NPC1L1 protein and inhibits the absorption of cholesterol

Question 14

where is NPC1L1 protein

Answer 14

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