THORACIC Section 9: Interstitial Lung Disease Flashcards

1
Q

What two main questions should you ask when presented with Interstitial Lung Disease?

A
  1. Acute or chronic?
  2. What is the primary finding?
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2
Q

What is this density that obscures underlying vessels?

A

Consolidation

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3
Q

What is this density that does NOT obscure underlying vessels?

A

Ground Glass opacity

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4
Q

It is the smallest part of the lung that is surrounded by connective tissue.

A

Secondary Pulmonary lobule

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5
Q

What runs in the middle of the secondary pulmonary nodule?

A

Terminal bronchiol and and artery

Airway and Artery

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6
Q

What runs at the periphery of the secondary pulmonary nodule?

A

Veins and Lymphatics

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7
Q

Described the pleural nodule pattern.

A

Random

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8
Q

Described the pleural nodule pattern.

A

Perilymphatic

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9
Q

Described the pleural nodule pattern.

A

Centrilobular

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10
Q

Pleural nodules that Abut the pleura

A

Perilymphatic or Random

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11
Q

Pleural nodules that does not abut the pleura

A

Centrilobular

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12
Q

Nodule vocabulary
Subpleura + peribronchovascular

A

Perilymphatic

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13
Q

Nodule vocabulary:
Not subpleural or peribronchovascular predominant

A

Random

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14
Q

Key Differentials

Perilymphatic nodule pattern

A

Sarcoid (90%)
Lympahgitic Spread of CA
Silicosis

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15
Q

Key Differentials

Random nodule pattern

A

Miliary TB
Metastasis
Fungal

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16
Q

Key Differentials

Centrilobular nodule pattern

A

Infection
RB-ILD (Respiratory Bronchilitis ILD)
Hypersensitivity Pneumonitis

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17
Q

This reticulonodular abnormality outlines the lobules’ characteristic shape and size (About 2 cm).

A

Interlobular Septal Thickening

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18
Q

Symmetric and smooth interlobular septal thickening is usually seen in what condition?

A

Pulmonary edema

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19
Q

Aymmetric and nodule interlobular septal thickening is usually seen in what condition?

A

Lymphangitic spread of neoplasm

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20
Q

Cystic areas of lung destruction in a subpleural location

A

Honeycombing

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21
Q

Hallmark of UIP

A

Honeycombing

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22
Q

What condition mimics honeycombing?

A

Paraseptal emphysema

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23
Q

One row of bubbles of subpleural cystic areas

A

Paraseptal Emphysema

23
Q

2-3 rows of bubbles of subpleural cystic areas

A

Honeycombing

23
Q

Causes of Interstitial Pneumonias

A

Idiopathic
Collagen vascular disease
medications
inhilation

24
Q

The MOST COMMON Interstitial Lung Disease (ILD)

A

Unutual Interstitial Pneumonia (UIP)

25
Q

First finding of UIP in X ray

A

Reticular pattern in the posterior costophrenic angle

26
Q

What is the definite UIP Criteria?

A
  1. Honeycombing (must be present) +/- traction bronchiectasis
  2. Reticular abnormalities
  3. Subplerual basal predominant distribution
  4. Absence of inconsistent features:
    Upper lobe
    GG>reticulations
    Air trapping involving 3 or more lobes
27
Q

Definite UIP pattern = Biopsy?

A

Doesn’t need a biopsy to prove diagnosis.

28
Q

UIP Buzzwords!

A

Apical to basal gradient
Traction bronchiectasis
Honeycombing
Heterogeneous on Histology

29
Q

Chronic hypersensitivity Pneumonitis (HP) vs IUP

Features favoring chronic HP?

A

Air Trapping involving 3 more lobes
Mid-upper lobe predominant fibrosis

30
Q

Pulmonariy fibrosis is a risk factor for?

A

Lung CA

31
Q

Cancer in fibrotic Lung favors what lobe?

A

Lower lobes

32
Q

Cancer in fibrotic Lung favors what interface?

A

Fibrotic cysts and normal lung

33
Q

ILD that is a common pattern in collagen vascular disease, and drug reactions

A

Nonspecific Interstitial Pneumonia (NSIP)

34
Q

ILD: Homogeneous inflammation or fibrosis

A

NSIP

UIP - heterogeneous

35
Q

Two FLAVORS of NSIP

A

Cellular or fibrotic

36
Q

NSIP Groundglass alone

A

Cellular

37
Q

NSIP GG+Reticulation

A

Cellular or fibrotic

38
Q

NSIP Reticulation + Traction Bronchiectasis

A

Fibrotic NSIP

39
Q

NSIP Honeycombing

A

Uncommon and minimal

40
Q

The most common ILD in scleroderma

A

NSIP

41
Q

ILD

Immediate subpleural sparing

A

NSIP

42
Q

NSIP vs UIP

Presence of micronodules

A

NSIP

43
Q

Apical Centrilobular ground glass nodules

A

Respiratory Bronchiolitis ILD (RB-ILD)

44
Q

More diffuse GGO, with patchy or subpleural distribution

A

Desquamative interstitial pneumonia (DIP)

45
Q

ILD showing Localized centrilobular ground glass nodules (due to macrophages filling up the terminal bronchioles).

A

RB-ILD

46
Q

Thought as an end spectrum of RB-ILD

A

DIP

47
Q

Filling of alveolar spaces with macrophages

A

DIP

48
Q

Peripheral lower lobe predominant GG with small cystic spaces

A

DIP

49
Q

This is a multi-system disease that creates “non-caseating granulomas.”

A

Sarcoid

50
Q

Classic triad of
Bilateral hilar lymph node enlargement
Arthtitis
Erythema nodosum

A

Acute Sarcoid

51
Q

bilateral hila and right paratracheal

A

1-2-3 sign in sarcoid

52
Q

Diagnosis?

A

NSIP

53
Q

Diagnosis?

A

UIP