THORACIC Section 5: LUNG CANCER - Subtypes Flashcards
What are the 4 main histological subtypes of Bronchogenic CA?
Non Small Cell Squamous CA
Non Small Cell Large Cell CA
Non Small Cell Adenocarcinoma
Small Cell
Strong Association with Smoking
Non Small Cell Squamous CA
Cavitation is Classic
Non Small Cell Squamous
Does NOT express the tissue marker thyroid transcription factor 1 “TTF-1” (other subtypes can
Non Small Cell Squamous
Central in location
Non Small Cell Squamous
and
Small Cell
Peripheral in Location
Non Small Cell Large Cell
Non Small Cell AdenoCA
Paraneoplastic Syndromes can be associated with ectopic Parathyroid Hormone
Non Small Cell Squamous CA
Least common Subtype (15%)
Non Small Cell Large Cell
Usually large (>4cm)
Non Small Cell Large Cell
Poor prognosis
Non Small Cell Large Cell
Most common Subtype (35%)
Non Small Cell AdenoCA
Favors the upper lobe
Non Small Cell AdenoCA
Most Common subtype to present as a solitary pulmonary nodule
Non Small Cell AdenoCA
Most common subtype in a NON SMOKER
Non Small Cell AdenoCA
Known association with pulmonary fibrosis
Non Small Cell AdenoCA
Strong association with smoking
AdenoCA
May only present with central lymphadenopathy
Small Cell
Most common primary lung CA to cause SVC obstruction and paraneoplastic syndromes
Small Cell
Terrible Horrible Incredibly Shitty Prognosis (metastasis early)
Small Cell
Paraneoplastic syndromes can be associated with SIADH and ACTH
Small Cell
Associated with the mythical Paraneoplastic Syndrome of LAMBER EATON
Small Cell
Proximal weakness from abnormal release of acetylcholine at the neuromuscular junction. The clinical presentation often comes before the cancer diagnosis
Lambert Eaton Syndrome in Small Cell
Common Symptoms
Central tumors:
Peripheral tumors:
Central tumors: hemoptysis
Peripheral tumors: pleuritic chest pain
