THORACIC Section 5: LUNG CANCER - Subtypes

Question 1

What are the 4 main histological subtypes of Bronchogenic CA?

Answer 1

Non Small Cell Squamous CA
Non Small Cell Large Cell CA
Non Small Cell Adenocarcinoma
Small Cell

Question 2

Strong Association with Smoking

Answer 2

Non Small Cell Squamous CA

Question 3

Cavitation is Classic

Answer 3

Non Small Cell Squamous

Question 4

Does NOT express the tissue marker thyroid transcription factor 1 “TTF-1” (other subtypes can

Answer 4

Non Small Cell Squamous

Question 5

Central in location

Answer 5

Non Small Cell Squamous
and
Small Cell

Question 6

Peripheral in Location

Answer 6

Non Small Cell Large Cell
Non Small Cell AdenoCA

Question 7

Paraneoplastic Syndromes can be associated with ectopic Parathyroid Hormone

Answer 7

Non Small Cell Squamous CA

Question 8

Least common Subtype (15%)

Answer 8

Non Small Cell Large Cell

Question 9

Usually large (>4cm)

Answer 9

Non Small Cell Large Cell

Question 10

Poor prognosis

Answer 10

Non Small Cell Large Cell

Question 11

Most common Subtype (35%)

Answer 11

Non Small Cell AdenoCA

Question 12

Favors the upper lobe

Answer 12

Non Small Cell AdenoCA

Question 13

Most Common subtype to present as a solitary pulmonary nodule

Answer 13

Non Small Cell AdenoCA

Question 14

Most common subtype in a NON SMOKER

Answer 14

Non Small Cell AdenoCA

Question 15

Known association with pulmonary fibrosis

Answer 15

Non Small Cell AdenoCA

Question 16

Strong association with smoking

Answer 16

AdenoCA

Question 17

May only present with central lymphadenopathy

Answer 17

Small Cell

Question 18

Most common primary lung CA to cause SVC obstruction and paraneoplastic syndromes

Answer 18

Small Cell

Question 19

Terrible Horrible Incredibly Shitty Prognosis (metastasis early)

Answer 19

Small Cell

Question 20

Paraneoplastic syndromes can be associated with SIADH and ACTH

Answer 20

Small Cell

Question 21

Associated with the mythical Paraneoplastic Syndrome of LAMBER EATON

Answer 21

Small Cell

Question 22

Proximal weakness from abnormal release of acetylcholine at the neuromuscular junction. The clinical presentation often comes before the cancer diagnosis

Answer 22

Lambert Eaton Syndrome in Small Cell

Question 23

Common Symptoms

Central tumors:

Peripheral tumors:

Answer 23

Central tumors: hemoptysis

Peripheral tumors: pleuritic chest pain