Thermodynamics of drug receptor binding Flashcards

1
Q

In the equation deltaG = -RT ln(Keq) what shows that a drug binds strongly to its target?

A

delta G large and negative

Keq large

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2
Q

In the free gibbs energy equation what shows a drug is good?

A

delta H large and negative

delta S is large and positive

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3
Q

What interactions occur for enthalpy change?

A
covalent 
electrostatic
H bonding
VDW
aromatic-aromatic
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4
Q

What are the 3 types of electrostatic interactions and which one is the strongest?

A

ion -ion Strongest
ion-dipole
dipole dipole

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