Thermodynamics of drug receptor binding Flashcards
1
Q
In the equation deltaG = -RT ln(Keq) what shows that a drug binds strongly to its target?
A
delta G large and negative
Keq large
2
Q
In the free gibbs energy equation what shows a drug is good?
A
delta H large and negative
delta S is large and positive
3
Q
What interactions occur for enthalpy change?
A
covalent electrostatic H bonding VDW aromatic-aromatic
4
Q
What are the 3 types of electrostatic interactions and which one is the strongest?
A
ion -ion Strongest
ion-dipole
dipole dipole