ACE inhibitors chemistry Flashcards
1
Q
What enzyme are ACE inhibitors derived from?
A
Carboxypeptidase
2
Q
How does carboxypeptidase bind to it’d receptor?
A
Zinc ion binds to oxygen ion ion interaction plarising carbonyl group
arginine forms ionic bond to terminal carboxylate group
hydrophobic interaction by aromatic ring to S1’
3
Q
What does angiotensin 2 do?
A
constrict b vessels increasing bp
4
Q
Which h amino acids are cleaved from angiotensin 1 to 2?
A
his, leu
5
Q
Why was a thiol added to ACE inhibitors but what are the side effects of this?
A
stronger interactions with zinc
side effects - rashes, loss of taste
