Chemistry of Statins Flashcards
1
Q
Where do LDLs carry cholesterol to?
A
cells
2
Q
Where do HDLs carry cholesterol to?
A
from cells to liver
3
Q
What is the rate determining step in the biosynthesis pathway of cholesterol
A
HMG coA to mevalonate
4
Q
Which enzyme do statin target?
A
HMG CoA reductase
5
Q
Which amino acids are involved in the catalytic mechanism in cholesterol?
A
lys, his, glu, asp
6
Q
Which are easier to synthesis type 1 or type 2 statins?
A
type 2
7
Q
Do statins with lower hydrophobic character target liver cells and have lower side effects?
A
yes
8
Q
Where does majority of cholesterol synthesis occur?
A
liver
