Platelet Integrin Chemistry Flashcards
1
Q
In the integrin Ligand binding site there are two subunits how does RGD bind to it
A
Two subunits in alpha D binds to metal ion of Mg2+
In the beta a negatively charged aspartate amino acid side chain forms an electrostatic salt bridge to the R
2
Q
In RGD what is the role of G?
A
Provides flexibility and allows peptide to stretch between the two pockets
3
Q
What increases the potency in KGDW?
A
The homo arginine
4
Q
What are the disadvantages of epitifibatide and tirofiban?
A
IV
tirofiban can’t bind and inhibit the function of avb3 receptors
5
Q
How does abciximab, eptifibatide and tirofiban work?
A
A - humanised monoclonal antibody directed against GPIIB and GPIIIa complex
E- fibrinogen analogue
T- non peptide competitive inhibitor
