Chemistey Of Antiplatelet Agents Flashcards
1
Q
How many transmembrane helices does the P2Y12 receptor have?
A
7
2
Q
Copidogrel forms what bond with cysteine?
A
Covalent
3
Q
What is the major side effect of clopidogrel?
A
Bleeding
4
Q
Which receptors does ATP have affinity for and is it highly charged?
A
P2
Yes
5
Q
Is Tricagrelor have reversibility? And what does higher doses cause?
A
Yes
Dyspnea and ventricular pause
6
Q
What is the difference between P2Y1 and P2Y12?
A
Activation of P2Y12 receptor by ADP doesn’t lead to PLC activation, intracellular ca2+ mobilisation and platelet conformation
