Theme 8 Flashcards
Function of Parasympathetic
not immediate
returns the body functions to normal after they have been altered by sympathetic stimulation.
7 Traits by Parasympathetic System:
SLUDDSA Sleep Lacrimination Urination Digestion Deification Salivation Sexual Arousal
What is the principla neurotransmitter in all autonomic ganglia?
Acetylcholine
What is the only neurotransitter in the motor division of the somatic nervous system?
Acetylcholine
Acetylcholine at neuromuscular junctions of skeletal muscle causes:
excitatory effect; contraction
Acetylcholine in cardiac tissue causes:
inhibitory effects ; lower heart rate
Two effects of acetylcholine?
- nicotinic
2. muscarinic
Nicotinic effects
post synaptic side of the neuromuscular junction is skeletal voluntary muscles.
Muscarinic effects
post ganglionic parasympathetic effect on the exocrine glands and on smooth cardiac muscles. (involuntary)
what type of Ach receptor is ionotropic? (ligand gated) in response to neurotransmitters?
Nicotinic
What Ach receptor is metabotropic and is coupled with G-proteins to change postsynaptic cells?
Muscarinic
Where are ionotropic receptors located?
muscle end plates
parasympathetic autonomic ganglia
the CNS
what stimulates Nicotinic ionotropic receptors?
Nicotine, acetylcholine
2 types of Nicotinic receptors:
muscular type
neuronal type
What type of receptors does curare inhibit?
muscle type nicotinic ionotropic receptor.
What type of receptors does hexamethonium inhibit?
neuronal type nicotinic ionotropic receptor.
Curare
common in south america;
non-depolarizing muscle relaxant
competitive antagonist
What is the Muscarinic cholinergic receptor?
7 transmembrane metabotropic receptor
Muscarine or muscarin
natural product found in certain mushrooms;
found in the fly agaric Amanita muscaria ;
activate muscarinic receptor
Both Muscarinic and Nicotinic receptors have what in common?
same specific neurotransmitters, acetylcholine
When ionotropic receptors are activated, it allows what ions to flow?
Na+, K+, or Cl-
When metabotropic receptors are activated, a series of intracellular events are triggered that do what?
Open Na+, K+, and Ca+++ channels
&& also activates intracellular signals.
Do ionotropic receptors or muscarinic receptors hanve long lasting effects and only remain open for a few miliseconds?
metabotropic receptors.
Atropine
inhibits the receptor that constricts the pupils;
from the plant “deadly nightshade”
Atropa belladonna
increase pupil size