Theme 8 Flashcards

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1
Q

Function of Parasympathetic

A

not immediate

returns the body functions to normal after they have been altered by sympathetic stimulation.

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2
Q

7 Traits by Parasympathetic System:

A
SLUDDSA
Sleep
Lacrimination
Urination
Digestion
Deification
Salivation
Sexual Arousal
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3
Q

What is the principla neurotransmitter in all autonomic ganglia?

A

Acetylcholine

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4
Q

What is the only neurotransitter in the motor division of the somatic nervous system?

A

Acetylcholine

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5
Q

Acetylcholine at neuromuscular junctions of skeletal muscle causes:

A

excitatory effect; contraction

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6
Q

Acetylcholine in cardiac tissue causes:

A

inhibitory effects ; lower heart rate

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7
Q

Two effects of acetylcholine?

A
  1. nicotinic

2. muscarinic

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8
Q

Nicotinic effects

A

post synaptic side of the neuromuscular junction is skeletal voluntary muscles.

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9
Q

Muscarinic effects

A

post ganglionic parasympathetic effect on the exocrine glands and on smooth cardiac muscles. (involuntary)

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10
Q

what type of Ach receptor is ionotropic? (ligand gated) in response to neurotransmitters?

A

Nicotinic

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11
Q

What Ach receptor is metabotropic and is coupled with G-proteins to change postsynaptic cells?

A

Muscarinic

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12
Q

Where are ionotropic receptors located?

A

muscle end plates
parasympathetic autonomic ganglia
the CNS

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13
Q

what stimulates Nicotinic ionotropic receptors?

A

Nicotine, acetylcholine

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14
Q

2 types of Nicotinic receptors:

A

muscular type

neuronal type

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15
Q

What type of receptors does curare inhibit?

A

muscle type nicotinic ionotropic receptor.

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16
Q

What type of receptors does hexamethonium inhibit?

A

neuronal type nicotinic ionotropic receptor.

17
Q

Curare

A

common in south america;
non-depolarizing muscle relaxant
competitive antagonist

18
Q

What is the Muscarinic cholinergic receptor?

A

7 transmembrane metabotropic receptor

19
Q

Muscarine or muscarin

A

natural product found in certain mushrooms;
found in the fly agaric Amanita muscaria ;
activate muscarinic receptor

20
Q

Both Muscarinic and Nicotinic receptors have what in common?

A

same specific neurotransmitters, acetylcholine

21
Q

When ionotropic receptors are activated, it allows what ions to flow?

A

Na+, K+, or Cl-

22
Q

When metabotropic receptors are activated, a series of intracellular events are triggered that do what?

A

Open Na+, K+, and Ca+++ channels

&& also activates intracellular signals.

23
Q

Do ionotropic receptors or muscarinic receptors hanve long lasting effects and only remain open for a few miliseconds?

A

metabotropic receptors.

24
Q

Atropine

A

inhibits the receptor that constricts the pupils;
from the plant “deadly nightshade”
Atropa belladonna
increase pupil size

25
Q

ACh activation of the metabotropic receptors causes what?

A

inhibition;
release of Ca2+
IP3 is the 2nd messenger aswell as Diacylglyerol

26
Q

the g-protein in metabotropic receptors:

A

PLC phospholipase C

27
Q

Where does Ca2+ come from?

A

endoplasmic reticulum

28
Q

Fast EPSP is associated with what type of receptor?

A

Nicotinic

29
Q

Postganglionic neurons are usually receptors of what type?

A

Nicotinic

30
Q

Hyperpolarization (IPSP) and slow depolarization (slow ESPS) that recover from stimulus in postganglionic neurons are mediated by what type of receptors?

A

M1, M2, muscarinic receptors