Theme 8 Flashcards

1
Q

Function of Parasympathetic

A

not immediate

returns the body functions to normal after they have been altered by sympathetic stimulation.

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2
Q

7 Traits by Parasympathetic System:

A
SLUDDSA
Sleep
Lacrimination
Urination
Digestion
Deification
Salivation
Sexual Arousal
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3
Q

What is the principla neurotransmitter in all autonomic ganglia?

A

Acetylcholine

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4
Q

What is the only neurotransitter in the motor division of the somatic nervous system?

A

Acetylcholine

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5
Q

Acetylcholine at neuromuscular junctions of skeletal muscle causes:

A

excitatory effect; contraction

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6
Q

Acetylcholine in cardiac tissue causes:

A

inhibitory effects ; lower heart rate

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7
Q

Two effects of acetylcholine?

A
  1. nicotinic

2. muscarinic

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8
Q

Nicotinic effects

A

post synaptic side of the neuromuscular junction is skeletal voluntary muscles.

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9
Q

Muscarinic effects

A

post ganglionic parasympathetic effect on the exocrine glands and on smooth cardiac muscles. (involuntary)

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10
Q

what type of Ach receptor is ionotropic? (ligand gated) in response to neurotransmitters?

A

Nicotinic

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11
Q

What Ach receptor is metabotropic and is coupled with G-proteins to change postsynaptic cells?

A

Muscarinic

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12
Q

Where are ionotropic receptors located?

A

muscle end plates
parasympathetic autonomic ganglia
the CNS

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13
Q

what stimulates Nicotinic ionotropic receptors?

A

Nicotine, acetylcholine

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14
Q

2 types of Nicotinic receptors:

A

muscular type

neuronal type

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15
Q

What type of receptors does curare inhibit?

A

muscle type nicotinic ionotropic receptor.

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16
Q

What type of receptors does hexamethonium inhibit?

A

neuronal type nicotinic ionotropic receptor.

17
Q

Curare

A

common in south america;
non-depolarizing muscle relaxant
competitive antagonist

18
Q

What is the Muscarinic cholinergic receptor?

A

7 transmembrane metabotropic receptor

19
Q

Muscarine or muscarin

A

natural product found in certain mushrooms;
found in the fly agaric Amanita muscaria ;
activate muscarinic receptor

20
Q

Both Muscarinic and Nicotinic receptors have what in common?

A

same specific neurotransmitters, acetylcholine

21
Q

When ionotropic receptors are activated, it allows what ions to flow?

A

Na+, K+, or Cl-

22
Q

When metabotropic receptors are activated, a series of intracellular events are triggered that do what?

A

Open Na+, K+, and Ca+++ channels

&& also activates intracellular signals.

23
Q

Do ionotropic receptors or muscarinic receptors hanve long lasting effects and only remain open for a few miliseconds?

A

metabotropic receptors.

24
Q

Atropine

A

inhibits the receptor that constricts the pupils;
from the plant “deadly nightshade”
Atropa belladonna
increase pupil size

25
ACh activation of the metabotropic receptors causes what?
inhibition; release of Ca2+ IP3 is the 2nd messenger aswell as Diacylglyerol
26
the g-protein in metabotropic receptors:
PLC phospholipase C
27
Where does Ca2+ come from?
endoplasmic reticulum
28
Fast EPSP is associated with what type of receptor?
Nicotinic
29
Postganglionic neurons are usually receptors of what type?
Nicotinic
30
Hyperpolarization (IPSP) and slow depolarization (slow ESPS) that recover from stimulus in postganglionic neurons are mediated by what type of receptors?
M1, M2, muscarinic receptors