The Somatosensory System Flashcards

1
Q

What 4 sub-senses are in the somatosensory system?

A

1.) Touch
2.) Pain
3.) Temperature
4.) Body location/Proprioception

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2
Q

Where does touch sensation occur?

A

The skin

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3
Q

What is the skin?

A

A combination of hairy and glabrous areas

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4
Q

What are 6 touch mechanoreceptors?

A

1.) Pacinian Corpsucle
2.) Merkel’s Corpsucle
3.) Ruffini’s Ending
4.) Meissner’s Corpsucle
5.) Free Nerve Ending
6.) Hair Follicle Recpetors

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5
Q

What is the largest touch mechanoreceptor?

A

Pacinian Corpsucle

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6
Q

What do hair follicle receptors do?

A

Respond to gross movement of the hair

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7
Q

Why are there so many types of mechanoreceptors?

A

There are many types of touch sensations to be transduced

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8
Q

Touch receptors vary in sensitivity to what 3 ways?

A

1.) Movement frequency
2.) Touch pressure
3.) Receptive field

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9
Q

What are receptive fields?

A

Areas on the skin to which an individual mechanoreceptor is sensitive

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10
Q

What is two-point discrimination?

A

How close do 2 points have to be to be perceived as one touch?

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11
Q

What is adaptation?

A

Duration of sustained touch time before mechanoreceptor stops responding

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12
Q

What is the role of a Pacinian Corpsucle?

A

Responds to compression and then release on the capsule that surrounds the axon

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13
Q

How do somatosensory neurons respond to movement?

A

Mechanosensitive ion channels respond to movement by opening Na+ or Ca2+ channels

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14
Q

How do somatosensory axons travel?

A

Travel from mechanoreceptor to spinal cord; enters SC through dorsl root ganglia

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15
Q

How many pairs of spinal nerves are there?

A

31

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16
Q

What is a dermatome?

A

The territory of touch sensitivity for each spinal nerve

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17
Q

What is the benefit of dermatome areas overlapping?

A

If one dorsal root is severed, the person does not lose all touch sensation in that dermatome region

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18
Q

What is the dorsal column-medial lemniscal pathway?

A

A distinct pathway that carries touch sensation up the SC to the brain (different from pain and temperature pathways)

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19
Q

What is the dorsal column-medial lemniscal pathway?

A

1.) Ascends up the dorsal column of the SC
2.) Terminates at dorsal column nuclei near the base of the medulla
3.) Axons then decussate to opposite side of the brain
4.) Ascend through medial lemniscus in brainstem
5.) Synapse with ventral posterior nucleus of the thalamus
6.) Project and terminate at the primary somatosensory cortex

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20
Q

Cranial nerve touch sensation reflects activation of which 4 cranial nerves?

A

1.) Trigeminal
2.) Facial
3.) Glossopharyngeal
4.) Vagus

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21
Q

Where is the primary somatosensory cortex located?

A

On the post-central gyrus in the parietal lobe

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22
Q

Which of Brodmann’s areas contain the primary somatosensory cortex?

A

Areas 1-3

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23
Q

What is somatotopy?

A

The map of the body’s touch sensations onto the brain

24
Q

What does the inferior portion of the primary somatosensory cortex represent?

A

Pharynx, tongue, jaw

25
What does the superior portion of the primary somatosensory cortex represent?
Face, fingers, hand, arms, trunk, thighs
26
What does the paracentral lobule of the primary somatosensory cortex represent?
Legs and feet
27
What is the role of the secondary somatosensory cortex?
Functional significance is unknown; may be a copy of primary area to protect against injury
28
Which of Brodmann's areas are the Somatosensory association cortex in?
5 and 7
29
What is the role of the somatosensory association cortex?
Integrates touch sensations with other sensory modalities
30
What are nociceptors?
Unmyelinated nerve endings that signal body damage/trigger the sensation of pain
31
What are 4 types of nociceptors?
1.) Mechanical 2.) Thermal 3.) Chemical 4.) Polymodal
32
What do mechanical nociceptors do?
Respond to injurious pressure levels
33
What do thermal nociceptors do?
Respond to damaging heat or cold
34
What do chemical nociceptors do?
Respond to histamines or injurious chemicals
35
What do polymodal nociceptors do?
Respond to multiple different stimuli types
36
What are transient receptor potential channels?
A channel for a neuron that is either cold sensitive or warm-sensitive; neurons only have one type
37
How many types of transient receptor potentials are there?
6; neurons only have one
38
Cold sensitive channels respond to what?
Menthol
39
TRPV1 warm-sensitive channels respond to what?
Capsaicin
40
What is the role of the spinothalamic pathway?
Conveys pain and temperature info up SC to brain
41
Where does the spinothalamic pathway decussate?
Immediately in the spinal cord
42
What do prostaglandins do?
Heighten sensitivity to pain , temperature, and touch generated by the breakdown of lipid plasma membranes
43
What can you think of when thinking about a prostaglandin?
A bruise that doesn't hurt unless you touch it
44
What does NSAID stand for?
Non-steroidal anti-inflammatory drugs
45
What do NSAIDs do?
Block prostoglandin synthesis to reduce inflammation
46
What are opioids?
A class of molecules that evoke nervous system changes by binding to opioid receptors
47
Where are opioid recpetors found?
In high density in the CNS nociceptive pathway
48
What is morphine?
A naturally occurring opioid found in opium that binds to opiod receptors
49
Why does the body have specialized receptors for morphine?
They are similar to endorphins produced within the CNS
50
What do endorphins do?
Triggers euphoria and pain relief
51
How do endorphins related to the sympathetic nervous system?
They prevent flow of pain information higher in the brain. They are good at managing acute pain, but not chronic pain
52
What drugs is morphine a key component of?
1. ) Hydrocodone/Vicodin 2.) Codeine 3.) Oxycodone/Oxycontin 4.) Heroin
53
Why are opioids addictive?
They cause euphoria and activation of pleasure centers in the brain
54
How do opioids become addictive?
Neurons adapt relatively quickly and the need for higher and higher doses results
55
How are opioids fatal?
1.) Opioid receptors in the brainstem are believed to inhibit breathing 2.) Reduced sensitivity to gag leads to aspiration
56
What is Naloxone?
An opioid receptor antagonist/blocker
57
What does Naloxone attempt to do?
It attempts to prevent overdose-induced inhibition of breathing and gag