The Nature of Airways Obstruction Flashcards
Th1 cells are associated with what Ig production?
IgG
Th2 cells are associated with what Ig production?
IgE
In asthma, how is FEV1 and FVC different compared to a healthy patient? What would the FEV1 / FVC ratio be?
FEV1 = reduced FVC = normal
Less than 0.7
How can you measure Eosinophillic levels in an Asthmatic patient?
Measure NO levels
What rare genetic condition can predispose you to COPD?
Alpha 1-antitrypsin deficiency
Outline the spirometry patterns in Asthma and COPD
In asthma = variation in FEV1 over time, will rise and fluctuate
In COPD = constant, reduced FEV1
How does the Bronchodilator response differ in Asthma and COPD?
In asthma = Bronchodilator response
In COPD = No bronchodilator response
How does the Corticosteroid response differ in Asthma and COPD?
In asthma = Corticosteroid response
In COPD = No corticosteroid response
How does Airway hyperreactivity differ in Asthma and COPD?
In asthma = Airway hyperreactivity
In COPD = No airway hyper-reactivity
What % improvement must there be in FEV1 following bronchodilation for it to be asthma?
15%
Outline the pathophysiology of Asthma
- Dendritic cells present to T cells
- Th2 cells signal via IL-4 B cells to produce IgE
- IgE binds to mast cells, causing degranulation
- Causes release of histamines and LKTs
- Th2 via IL-5 cause activation of Eosinophils
When are Wheezes commonly heard?
On expiration
When is Stridor commonly heard?
On inspiration
