Pharmacology of Rhythm Control Flashcards
What is the resting potential of a Cardiac Action Potential?
-90mV
Explain what happens in Phase 4 of the Cardiac Action Potential
The potential is -90mV. Na+ and Ca2+ channels are closed, however K+ rectifier channels are open
Explain what happens in Phase 0 of the Cardiac Action Potential
Rapid depolarisation. Na+ channels open, due to influx of Na+ entering the cell
Explain what happens in Phase 1 of the Cardiac Action Potential
Rapid repolarisation, due to closure of Na+ channels and transient channels opening. K+ moves out
Explain what happens in Phase 2 of the Cardiac Action Potential
Delay repolarisation. L-type Calcium channels open and Ca2+ moves in. K+ still moves out
Explain what happens in Phase 3 of the Cardiac Action Potential
Second repolarisation. K+ continues to move out, but Ca+ channels now close
What is the intrinsic firing rate of the Sinoatrial node?
105 bpm
At rest, how is the SAN influenced?
At rest, parasympathetic and sympathetic feed is active, but vagal inhibition dominates
What is the intrinsic firing rate of the Bundle of His?
40 bpm
What is the speed of conduction in the Atria?`
1 m/s
What is the speed of conduction in the AVN?
0.05 m/s
What is the speed of conduction in the Bundle of His?
2 m/s
What is the speed of condunction in the Purkinje fibres?
4 m/s
What is the speed of condunction of the Ventricles?
1 m/s
What does ARP stand for? What does it mean?
Absolute Refractory Period, a period where the heart cannot be excited
What does RRP stand for? What does it mean?
Relative Refractory Period, a period where the heart could be vulnerable to excitation
Outline the types of AV block
- First degree block
- Second degree, Mobitz Type 1 block (Wenklebach)
- Second degree, Mobitz Type 2 block
- Third degree block