The cornea

Question 1

give 5 roles of basement membranes

Answer 1

1. a structural role in maintaining tissue architecture.
2. providing anchorage for adjacent cells
3. being a selective barrier to migrating or invading cells.
4. facilitating filtration or temporary storage of macromolecules.
5. being intimately involved in the biological processes, such as embryonic development and cellular differentiation.

Question 2

what is the predominant collagen type in the cornea?

Answer 2

type 1

Question 3

what are the 3 sources of nutrients for the cornea?

Answer 3

tear film - most of the oxygen
limbal blood vessels
aqueous humour - glucose and amino acids

Question 4

give 6 potential causes for endothelial degeneration

Answer 4

Age
Intraocular inflammation
Anterior lens luxation
Increased IOP
Intraocular mass
Intraocular surgery / trauma

Question 5

what is the predominant lipid in corneal lipid dystrophy?

Answer 5

cholesterol

Question 6

name 4 breeds most commonly affected by endothelial dystrophy

Answer 6

English Springer Spaniel,
Chihuahua,
Boxer
Boston Terrier

Question 7

what gene is involved in macular corneal dystrophy?

Answer 7

Carbohydrate Sulfotransferase-6 gene mutation

Question 8

what 2 bacteria are common causes of corneal melts?

Answer 8

pseudomonas spp and b-haemolytic streps

Question 9

what are the 2 most important glycosaminoglycans in to stroma?

Answer 9

keratan and dermatan sulphate

Question 10

what are the 3 phases of healing for corneal epithelial defects?

Answer 10

First phase – epithelial cell elongation followed by migration
Second phase – marked cell proliferation
Third phase – cellular differentiation

Question 11

name 4 factors that regulate and control epithelial cell migration in mammalian species

Answer 11

epidermal growth factor,
transforming factor growth-beta,
keratinocyte growth factor
substance P

Question 12

true or false: autologous serum is effective against both serine proteases and MMPs

Answer 12

true

Question 13

name 5 breeds that are commonly affected by crystralline stromal dystrophy (lipid dystrophy)

Answer 13

Cavalier King Charles Spaniel, 
Siberian husky
samoyed
rough collie
Airedale Terrier