The 15 Tenets of Inflammation Flashcards
vessels primarily affected by inflammation?
Arterioles (Vasodilation)
Post capillary venules (Vascular permeability and cell emigration)
5 cardinal signs of inflammation?
Reddness, Swelling, Heat, Pain, Loss of Fxn
Cells primarily involved in the initiation/early phases are…
Endothelial and Mast Cells
Mast cells release early mediators in response to…
Trauma, Cold, Complement, IgE
When fluid alone passes through a vessel, you have a….
transudate
Doesn’t require increase in vascular permeability
When fluid + proteins + cells pass through a vessel you have…
exudate
Requires increased vascular permeability
Neutrophils die off within…
48-72 hours
Macrophage response begins after…
24 hours
First mediators of inflammation (list a couple) are replaced by ones from macrophages (list a couple)
1st – Histamine and Kinins
2nd – cytokines and prostaglandins
How does inflamm. get turned off?
Most mediators are only short lived and acute phase proteins supply anti-inflammatory signals and neutralization of inflamm. mediators.
