Principles of Healing and Regeneration Flashcards
______ are the main component of granulation tissue
Fibroblasts.
The provide the collagen that makes a provisional environment for parenchymal cell proliferation.
____ is a key factor in fibroblast proliferation and fibrosis
TGF-b.
It mediated chronic fibrosis in many disease states.
How do fibroblasts organize/collagen strengthenq
Contraction of myoepithelial cells
Wound strength is at ___% after the first week and ____% by the 3rd month.
10%
70-80%
Last component of tissue regeneration
reinnervation
Granulation tissue is characterized by..
Loose, edamatous stroma with proliferating fibroblasts and multiple tiny arteries. Principle multiplying cells are fibroblasts and endothelial cells (angiogenesis).
What occurs in healing by first intention?
Wound edges are pulled together to minimize tissue defect. Intact basement is aligned for easy epithelization. Minimal damage to architecture.
What occurs in healing by second intention?
Large tissue defect due to ulcer, abscess, or extensive necrosis.
Wound contraction must occur on maturation of the granulation tissue. Contracture of the scar.
Most common factor inhibiting resolution of the healing process?
Infection
Collagens associated with the wound healing process
I and II
Cross linking of collagen requires…
Calcium and Vitamin C
Which adhesion molecules are Ca dependent? Which ones are not?
Dependent – Selectins + Cadherins
Indep – Integrins + Ig super family
What do cadherins do?
Mediate homotypic adherence between like cells and are tissue specific
Two important stimulators of angiogenesis?
FGF, VEGF
_____ help cleave the ECM during angiogenesis
MMPs
