Tetracyclines - Doxycycline Flashcards
1
Q
What are common indications for the use of doxycycline?
A
- Acne Vulgaris
- LRTI
- Infective exacerbation of COPD
- Pneumonia
- Atypical pneumonia
- PID
- Chlamydia
- Typhoid
- Anthrax
- Malaria
2
Q
How do tetracylines work?
A
Inhibit bacterial protein synthesis
3
Q
What are important adverse effects of tetracyclines?
A
- Nausea
- Vomiting
- Diarrhoea
- Hypersensitivity
- Oesophageal irritation/ulceration/dysphagia
- Photosensitivity
- Discolouration of tooth enamel
- Intracrenial hypertension
4
Q
When are tetracyclines contraindicated?
A
- Pregnancy
- Breastfeeding
- Children under age of 12 years
5
Q
What are important interactions which occur with tetracyclines?
A
- Calcium
- Antacids
- Iron
- Warfarin
6
Q
When should tetracyclines be given in relation to calcium, antacids or iron supplements?
A
2 Hours after administration of calcium, iron or antacids
7
Q
What routes can tetracyclines be given?
A
Oral only
8
Q
What is the dose of doxycycline usually given?
A
100-200 mg daily
9
Q
What advice would you give to someone taking tetracyclines?
A
Wash down with water or take whilst standing - stops them getting stuck and causing ulceration
