Flucloxacillin Flashcards
1
Q
What are common indications for flucloxacillin use?
A
- Skin/soft tissue infection
- Osteomyelitis
- Septic arthritis
- Endocarditis
- Other infections
2
Q
Why is flucloxacillin effective against B-lactamase producing bacteria?
A
Acyl side chain protects the B-lactam ring from B-lactamases
3
Q
How does MRSA resist the action of flucloxacillin?
A
Reduces penicillin binding affinity
4
Q
What are important side effects of flucloxacillin?
A
- GI upset
- Allergy
- Liver toxicity - cholestasis, hepatitis
- CNS toxicity
5
Q
When is flucloxacillin contraindicated for use?
A
Prior Fluclox-related hepatotoxicity
6
Q
What is the dose regimen used for administering flucloxacillin in an adult using oral tablets?
A
250-500 mg 4 times per day
7
Q
Why does flucloxacillin need to be administered 6-hrly?
A
Short plasma half-life of 45-60 minutes - excreted renally
8
Q
How might you monitor efficacy of flucloxacillin?
A
- Symptoms/signs
- Blood markers
