Quinolones - Ciprofloxacin, levofloxcin Flashcards
1
Q
What are quinolones commonly used for?
A
Second/third line treatment for:
- UTI
- Severe GI infection
- LRTI
- Pseudomonas Aeruginosa
2
Q
How do quinolones work?
A
Kill bacteria by inhibiting DNA synthesis
3
Q
What organisms are quinolones particularly effective against?
A
Gram-negative organisms
4
Q
What adverse reactions can occur with quinolones?
A
- GI upset
- Hypersensitivity
- Hallucinations
- Lowering of seizure threshold
- Rupture of muscle tendons
- Prolonged QT interval
- C. diff infection
5
Q
What drugs can quinolones interact with?
A
- Thephylline
- NSAIDs
- Prednisolone
- Amiodarone
- Antipsychotics
- Quinine
- Macrolides
- SSRIs
6
Q
Why does ciprofloxacin cause theophylline toxicity?
A
Inhibits cytochrome P450
7
Q
What can occur due to interactions between NSAIDs and ciprofloxacin?
A
Increased risk of seizures
8
Q
What dose of ciprofloxacin should be used for repiratory tract infections if given orally?
A
500-750 mg twice daily
9
Q
What dose of ciprofloxacin should be given orally for UTI?
A
250-750 mg
10
Q
What GI infections are quinolones particularly good at treating?
A
- Traveller’s diarrhoea
- Shigella
- Salmonella
- Campylobacter
