Test 5: The Platelet and Primary Hemostasis COPY Flashcards
Is the process that maintains flowing blood in a fluid state and prevents loss of blood from sites of vascular injury.
Hemostasis
Normal hemostasis is dependent upon…
-integrity of vascular wall
- Platelets
-Coagulation system
-fibrinolytic system 
What are the stages of hemostasis?
-primary Hemostasis (Formation of platelet plug)
-Secondary hemostasis (Incorporation of fibrin and coagulation factors to form the secondary hemostatic plug (fibrin clot)
-fibrinolysis (Break down and removal of clot formed) 
Primary hemostasis consists of what two key parts?
-The vascular system
-Platelets
Vascular system consists of three types of blood vessels: 
-arteries and arterioles
-veins and Venules
-capillaries
______________ provides a smooth barrier between circulating blood and body tissues
Vascular intima
Vascular intima:
The innermost lining is a ___________ of endothelial cells.
Monolayer
Capillaries consist of a layer of endothelial cells on a basement membrane and surrounded by __________ -No smooth muscle or fibroblasts 
Pericytes
Functions of the endothelial cells are supported by the surrounding __________ and smooth muscles cells.
Fibroblasts
 The vascular intima functions to promote….
Coagulation and anticoagulation
-When intact, the endothelial cells produce anticoagulant properties
-When damaged the endothelial cells produce pre-coagulant properties
 -The average diameter of platelets in the circulation is _____ Microns

2.5
The average number of platelets is…
140,000 to 450,000/ cmm 
Play the structure is divided into what three zones?
-peripheral
-Structural/Sol-gel
-Organelle zones