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Hematalogy Lecture > Heme Exam C > Flashcards

Heme Exam C Flashcards

1
Q

Aplastic anemia if RPI is…

A

<2

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2
Q

How do you calculate RPI?

A

Retic % x [Hct./45]

divided by

maturation time in days

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3
Q

HJ is seen in ____________anemia.

A

megaloblastic

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4
Q

Warm Auto, which cell is seen?

A

spherocytes

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5
Q

Cold Auto will have which cells?

A

spherocytes and schistocytes

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6
Q

Osmotic fragility with thalassemia?

A

decreased

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7
Q

Which test is not important to differentiate IDA and thalassemia?

A

OF,SI,Sfe

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8
Q

What is associated with babies with kidney disease?

A

HUS

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9
Q

CD marker for PNH?

A

16, 48, 55, 59

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10
Q

Acute Acquired Red Cell Aplasia is usually following a ______ infections, in which some viruses attack the erythroblasts

A

viral

-There is no need for any treatment, as it is cleared along with the virus

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11
Q

:genetic and is usually manifested in infants below the age of
one, they have similar characteristics of Fanconi’s anemia such as microcephaly, short stature, skeletal deformities

A

Diamond Blackfan Syndrome

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12
Q

What is the diagnostic test for Diamond Blackfan Syndrome?

A

an enzyme assay for Adenosine deaminase

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13
Q

Does IDA or ACD have a high RDW?

A

IDA

-ACD is fairly normal (due to sufficient iron stores)

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14
Q

What is TIBC with IDA?

A

normal or increased

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15
Q

What is TIBC with ACD?

A

normal or decreased

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16
Q

measures iron in…plasma/serum
-the Fe3+ form of iron that is bound to the transport protein transferrrin in the plasma

A

Serum iron

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17
Q

What lab values are associated with sideroblastic anemia?

A

-SI increased
-TIBC decreased or normal
-Prussian blue for pappenheimer inclusions
- >10% sideroblasts in the BM
-These are the siderotic granules ppt, due to not proper iron being put into the heme. They are Fe3+ form. ( insoluble)

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18
Q

___% of iron in the body is the form of hemoglobin

A

70

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19
Q

EPO in intravascular hemolysis is…

A

increased

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20
Q

Hgb that has FE3+ and 1% in adult

A

Methemoglobin

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21
Q

What the normal adult hemoglobin?

A

-

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22
Q

What is the normal fetal hemoglobin?

A

-

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23
Q

Which pathway removes oxidative stress?

A

hexose monophosphate

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24
Q

Which changes methemoglobin to hemoglobin?

A

hexose monophosphate

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25
Q

Iron that binds to hemoglobin is in what state?

A

ferrous

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26
Q

Intravascular hemolysis –> _________ haptoglobin

A

decreased

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27
Q

iron is stored in the form of soluble _________ and insoluble _________.

A

ferritin, hemosiderin

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28
Q

Normal SI range?

A

50­-170

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29
Q

Normal TIBC range?

A

250-450

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30
Q

Normal Se Ferritin range?

A

10-120

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31
Q

KB stain is for

A

alpha2 gamma2

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32
Q

Erythropoietin will stimulate which CFU?

33
Q

Intravascular hemolysis is characteristic of which cell/cells?

34
Q

Pernicious anemia is not a B12 deficiency its an _________ problem.

A

intrinsic factor

35
Q

How are dacrocytes formed?

A

when the cells attempt to pass through the microcirculation resulting in the pinching the cell as the part containing the inclusion is left behind.

36
Q

what crystals is associated with nephrotic syndrome

A

cholesterol crystals

37
Q

Will RDW be increased or decreased with IDA?

38
Q

Beta thalassemia has decreased hgb A and increased hgb ____ and hgb ____

39
Q

urobilinoginurua , hemoglobinuria and hemosiderinuria are characteristic of which hemolysis?

A

intravascular

40
Q

45% hgb S and 46% hgb C is characteristic of what disease?

A

Hemoglobin S/C disease

41
Q

Which thalassemia has the MOST codocytes?

A

Beta major???

42
Q

CRC formula

A

reticulocyte % × (patient Hct/normal Hct)

43
Q

What is the difference between polychromatic cells and reticulocytes?

A

Polychromasia and reticulocytes are the same cell with wright and supravital stain respectively

44
Q

Valine for glutamic acid is hgb ___

45
Q

Lysine for glutamic acid if hgb ___

46
Q

hypersegmented neutrophils is seen in what type of anemia?

A

megaloblastic anemia

47
Q

Malaria dugs can cause what deficiency?

48
Q

Ture or false: All polychromatophilic cells are reticulocytes

49
Q

Hemoglobinpath. Vs thal.

A

Thal = decreased rate of SYNTHESIS
Hgb = DNA Mutation and structure

50
Q

What is the last stage of erythrocyte maturation that is capable of mitosis?

A

Polychromatic erythroblast

51
Q

what is the order of RBC maturation?

A

-pronormoblast
-basophilic normoblast
-polychromatic normoblast
-orthochromic
-polychromatic
-erythrocyte

52
Q

IDA vs ACD - ferritin

A

IDA- low
ACD- normal or increased

53
Q

CBC w/ increased MCV and increased total bilirubin and LDH…what test should be ordered next?

A

B12 folate DNA synthesis testing

54
Q

LD with IgM that binds to complement

55
Q

Cooley Anemia is another name for…

A

Beta Thal. Major

56
Q

yellow crystals in macrophages?

A

Bilirubin crystals

57
Q

Kidneys stone type seen in children

A

Calcium stones (oxalate and phosphate)

58
Q

Serum FA-ABS pos and VDRL CSF neg, what does it mean?

A

neurosyphillis

59
Q

Melituria is due to…

A

sugar in the urine

60
Q

glucosuria and acidic urine is associated with…

61
Q

Severe intrinsic hemolytic anemia will have what change

A

decreased haptoglobin

62
Q

Guthrie test control

A

Bactillius subtilis is incubated on a media of known blood concentration

63
Q

what is the most common cause of end stage renal disease?

A

Diabetic nephropathy

64
Q

What is the relative protein concentrations between CSF and serum?

A

concentration is much lower in CSF!

65
Q

What is the normal amount of CSF in an adult?

A

around 140 mL

66
Q

An athlete is training and his increase/decrease 2,3BPG will cause an increase/decrease to his hemoglobin’s affinity for oxygen

A

Increase in 2,3BPG will decrease Hgb O2 affinity and increase O2 offloading to the tissues

67
Q

Normal CSF protein and glucose levels?

A

15–40 mg/dL protein
50–80 mg/dL (two thirds of blood glucose)

68
Q

What disease causes large amounts of branched-chain amino acids to be excreted in the urine?

A

Branched-chain α-ketoacid dehydrogenase deficiency, commonly known as Maple Syrup Urine Disease (MSUD),

69
Q

megaloblastic anemia is associated with what inclusions?

70
Q

-Lithotripsy is a procedure that…

A

uses shock waves to break up stones in the kidney

71
Q

What are Cabot rings composed of?

A

remnants from mitotic spindles

72
Q

Which organic acidemia produces urine with an odor of “sweaty feet”?

A

Isovaleric acidemia

73
Q

Abnormal amounts of indigo blue in the urine are indicative of a defect in the metabolism of

A

Tryptophan

74
Q

The finding of increased amounts of the serotonin degradation product 5-HIAA in the urine indicates:

A

Argentaffin cell tumors

75
Q

Renal tubular epithelial cells and casts are significant for what condition?

A

Acute tubular necrosis

76
Q

Analysis of urine from an infant whose mother reported a blue staining on the diapers showed increased levels of indican and a generalized aminoaciduria. On the basis of these findings, the infant was diagnosed as having:

A

Hartnup disease

77
Q

The finding of a “blue diaper” is indicative of a defect in the metabolism of:

A

Tryptophan

78
Q

What is the last stage in erythropoiesis that can Undergo mitosis and divide

A

Polychromatophilic normoblast

79
Q

a hemolytic disorder caused by Donath Landsteiner IgG autoantibody that binds to red cells in the cold, and causes hemolysis of the cells when complement activated at warmer temperatures

Hematalogy Lecture (35 decks)

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