Test 3: Intro to Anemia Flashcards
Reticulocyte count tells how well the _____________ is responding. 
 bone marrow 
The lifespan of RBC in circulation is _____ days.
Approximately ____ percent of circulating RBCs are lost daily
120
1
Receptors in kidney are sensitive to changes in oxygen tension/concentration.
When O2 tension drops, more ______ Is made by kidney and released into the blood stream to stimulate bone marrow normoblasts.
EPO
What are the effects of erythropoietin? 
-bone marrow allows for early release of reticulocytes
-Increases the number of mature Erythrocytes
-increases the rate of maturation of erythroid precursors (Accelerated release affect in peripheral blood) 
Does EPO expand the lifespan of RBCs?
NO!
lifespan is always 120 days
Normal bone marrow response to EPO can increase erythropoiesis ______ fold*, But it takes a full week for complete response to occur! 
6-8
Erythropoietin can cause shift Reticulocytes to be seen in peripheral blood in about _____ days. 
2
-Increased retic count
-increased RPI (Reticulocyte production index) 
A calculation which indicates whether or not bone marrow is responding adequately to anemia
RPI (reticulocyte production index) 
Red cell disorders can be classified as either __________ or _________. 
Erythrocytosis, Anemias
What are the two disorders that present with an increase in circulating RBC (Increased Hct.)? 
• Erythrocytosis
• Polycythemias 
___________ are disorders that present with a decrease in circulating RBCs (Decreased hematocrit) 
Anemias
(Think of rule of 3- Hemoglobin and Hematocrit are directly related) 
Diagnosis of anemia is based on…
-history
-Physical examination
-Symptoms
-Lab results
A reduction in the hemoglobin content of blood that can be caused by a decrease in the RBC count, hemoglobin concentration, and hematocrit below reference range for healthy individuals of similar environmental conditions
Anemia
Anemia can be related to what three values?
-low RBC count
-decreased Hemoglobin
-Low hematocrit
Anemia that causes a decrease in the oxygen carrying capacity of the blood due to too little hemoglobin or ___________ hemoglobin
Dysfunctional