Platelet Structure And Function Flashcards
Where are megakaryocytes found?
Only in bone marrow and not in peripheral blood
Largest cell in the bone marrow
Megakaryocytes
Megakaryocyte mission is to proliferate and release fragments of _____________ Into circulation. 
Cytoplasm (Platelets) 
 Megakaryocytopoiesis Is controlled by growth factors such as….
Interleukins and thrombopoietin (TPO, a renal hormone)
From the kidneys (Also from liver and spleen) Is a major growth factor for megakaryocytic progenitor cells to mature and release Platelets
Thrombopietin (TPO) 
What is the old name for platelets?
Thrombocytes
What is the normal platelet range? 
150 to 450,000 µL
Where are megakaryoblasts or MK-I found? 
In bone marrow only
megakaryoblasts or MK-I nucleus undergoes __________. 
Endomitosis
megakaryoblasts (MK-I) nucleus…
Overlapping nuclear lobes (Can only see one)
megakaryoblasts (MK-I) cytoplasm…
Contain scanty, blue cytoplasm, and no granules yet*
megakaryoblasts (MK-I) N:C ratio is _______
High
megakaryoblasts (MK-I) size?
14 to 18 micrometers
can megakaryoblasts (MK-I) be classified by visual morphology? 
No! Cannot be classified by visual morphology alone! 
How to Promegakaryocytes (MK-2) composite to megakaryoblasts (MK-I) in size?
Larger (14 to 30 µm) 
- an exception to the rule that older cells get smaller
Promegakaryocytes (MK-2) nucleus…
Becomes lobulated or indented