Test 5: Secondary Hemostasis Flashcards
Process by which body spontaneously stops bleeding, AND SIMULTANEOUSLY MAINTAINS BLOOD IN A FLUID STAY, WITHIN THE VASCULAR COMPARTMENT.
Hemostasis
What are the four major systems involved in maintaining hemostasis?
• vascular system, and platelets = primary hemostasis
• coagulation, and fibrinolytic system = Secondary hemostasis
Upon vessel injury, platelets immediately adhere to ___________ connective tissue.
Subendothelial
Upon vessel injury, pits. immediately adhere to subendothelial connective tissue.
• Thus this process has 3 separate processes:
• Adhesion
•Aggregation
• Secretion
These steps yield an unstable platelet plug
Secondary hemostasis leads to the formation of a stable ________ clot around the platelet plug (which was previously formed by primary hemostasis)
Fibrin
The pathways in secondary hemostasis are _____ processes that take place on the surface of platelets, or an endothelial cell plasma, membrane phospholipids
3D
Can secondary hemostasis pathways occur on lipids? (absence of a cell surface)
Yes (important for clotting time assays)
In the coagulation cascade, there are _______ coagulation factors, and _____ are enzymes and others are cofactors.
16, 8
Enzymes in secondary hemostasis…
-Serine proteases (cleve peptide bonds, and have serine residue in active sites)
-zymogens
-do the actual binding to the phospholipids (using calcium as a cofactor)
Inactive enzymes are called ___________, must be modified to become active
Zymogens
___________ bind to the enzymes, making the enzymes more stable and reactive
Cofactors
Name for factor one
Fibrinogen
Name for factor two
Prothrombin
Name for factor three
Tissue thromboplastin
Name for factor IV
Plasma calcium
