Test 5: Secondary Hemostasis

Question 1

Process by which body spontaneously stops bleeding, AND SIMULTANEOUSLY MAINTAINS BLOOD IN A FLUID STAY, WITHIN THE VASCULAR COMPARTMENT.

Answer 1

Hemostasis

Question 2

What are the four major systems involved in maintaining hemostasis?

Answer 2

• vascular system, and platelets = primary hemostasis
• coagulation, and fibrinolytic system = Secondary hemostasis

Question 3

Upon vessel injury, platelets immediately adhere to ___________ connective tissue.

Answer 3

Subendothelial

Question 4

Upon vessel injury, pits. immediately adhere to subendothelial connective tissue.
• Thus this process has 3 separate processes:

Answer 4

• Adhesion
•Aggregation
• Secretion
These steps yield an unstable platelet plug

Question 5

Secondary hemostasis leads to the formation of a stable ________ clot around the platelet plug (which was previously formed by primary hemostasis)

Answer 5

Fibrin

Question 6

The pathways in secondary hemostasis are _____ processes that take place on the surface of platelets, or an endothelial cell plasma, membrane phospholipids

Answer 6

3D

Question 7

Can secondary hemostasis pathways occur on lipids? (absence of a cell surface)

Answer 7

Yes (important for clotting time assays)

Question 8

In the coagulation cascade, there are _______ coagulation factors, and _____ are enzymes and others are cofactors.

Answer 8

16, 8

Question 9

Enzymes in secondary hemostasis…

Answer 9

-Serine proteases (cleve peptide bonds, and have serine residue in active sites)
-zymogens
-do the actual binding to the phospholipids (using calcium as a cofactor)

Question 10

Inactive enzymes are called ___________, must be modified to become active

Answer 10

Zymogens

Question 11

___________ bind to the enzymes, making the enzymes more stable and reactive

Answer 11

Cofactors

Question 12

Name for factor one

Answer 12

Fibrinogen

Question 13

Name for factor two

Answer 13

Prothrombin

Question 14

Name for factor three

Answer 14

Tissue thromboplastin

Question 15

Name for factor IV

Answer 15

Plasma calcium

Question 16

Name for factor V

Answer 16

Labile factor

Question 17

Name for factor VII

Answer 17

Stable factor

Question 18

Name for factor VIII

Answer 18

Antihemophilic factor

Question 19

Name for Factor IX

Answer 19

Christmas factor

Question 20

Name for factor X

Answer 20

Stuart-Prower factor

Question 21

Name for factor XI

Answer 21

Plasma thromboplastin antecedent (PTA)

Question 22

Name for factor XII

Answer 22

Hageman factor

Question 23

Name for factor XIII

Answer 23

Fibrin-stabilizing factor (FSF)

Question 24

Name for Prekallikrein

Answer 24

Fletcher factor (Pre-K)

Question 25

High-molecular-weight kininogen (HMWK) is called…

Answer 25

Fitzgerald factor

Question 26

platelet factor three…

Answer 26

Platelet phospholipids