Test # 5 Pain 2

Question 1

What are three abortive treatments for Migraines?

Answer 1

NSAIDS - rarely works
Ergot alkaloids - mushrooms - LSD
Triptans - best one! 80% success in first dose

Question 2

What are three -triptans that are used to treat migraines. They are 5-HT agonist (increase it in the brain).

They constrict intracranial BV (which is painful), decrease swelling, and decrease plasma extravasation

Answer 2

Sumatriptans
Naritryptan
Zolpitriptan

Question 3

What are 4 other abortive drugs that can be used for migraines?

Answer 3

Phenothiazines
Isometheptene
Propranolol
Butorphanol

Question 4

Many, Many prophylactic treatments for migraines.

Answer 4

Ca++ channel blockers
Cyproheptadine
Ergotamine
Amitripyyline
Clonidine
Methysergide
Sodium Valproate
NSAIDS
Fluoxetine

Question 5

What is the prototype drug for:
Amides -
Esters -

Answer 5

Amides - Lidocaine - liver metabolism

Esters - Procaine - plasma hydrolysis

Question 6

What is the main MOA of local anesthetics?

Answer 6

Na+ channel Blockers!!

But must cross membrane to work

Question 7

What is the prototype drug for:

Amides - onset is 10min, duration 1hr

Answer 7

Lidocaine

Question 8

A local that crosses the placental, (not good for c/s), duration 1-5hrs

Answer 8

mepivicaine

Question 9

A local - amide, that can produce methemoglobinemia (blue man), little vasodilation

Answer 9

Prilocaine

Question 10

a local that had a long duration (8-12hrs); don’t use in cardiac patients.

Answer 10

Bupivicaine

Question 11

a local that had a long duration (8-12hrs); but can be used in cardiac patients

Answer 11

Ropivacaine

Question 12

A local amide that has a fast onset (t like bc its too quick

Answer 12

Etidocaine

Question 13

A local similar to lidocaine that Dentist LOVE. 60 min duration

Answer 13

Articaine

Question 14

A local that is a potent Ester. In Aloe Vera. good topical

Answer 14

Tetracaine

Question 15

What is the first synthetic local that has a 15min duration. Must frequently re-inject. More ppl are allergic to it

Answer 15

Procaine (Novacaine)

Question 16

The first local - back to the stone age. It is a vasoconstrictor so don’t mix with epi!! First used a Charity in NOLA

Answer 16

Cocaine

Question 17

What is one drug that only treats Gout pain by inhibiting the migration of granulocytes into inflamed area thus reducing the release of lactic acid

SE - inhibits cell division - slows things down

Answer 17

Colchicine

Question 18

What drug helps with Gout. It inhibits the enzyme, Xanthine Oxidase
Must use low dose for renal compromised patients

Answer 18

Allopurinol

Question 19

What is also a drug for Gout that is an Xanthine oxidase inhibitor. SE - liver probs, gout flares, and rash - guy carrying a Erlenmeyer flask

Answer 19

Febuxostat (uloric)

Question 20

What is a uricosuric drug that increases the excretion of uric acid. Helps decrease excretion of penicillin so you can lower the dose

Answer 20

Probenecid

Question 21

What is a uricosuric drug that increases the excretion of uric acid by inhibiting the re-absorption.

Answer 21

Sulfinpyrazone

Question 22

What causes the neuropathic pain?

Answer 22

An increase production of Na channels = amplification in the pain message

Question 23

What is the #1 antidepressant drug used as an analgesic?

They block the reuptake of 5-HT and NE

Answer 23

Amitriptyline

Dose is much lower for analgesia and work immediately rather than a few days for depression

Question 24

What is the most popular anticonvulsant and which one is taking over the market?!? he said twice!!

Answer 24

Carbamazepine

Gabapentin - lower SE