Test # 4 Sex Hormones Flashcards
What forms of estrogen are produced and secreted by the ovaries
Estradiol and Estrone
What form of estrogen is also made in the adrenal gland and other organs for males
Estrone
What is the most commonly used HRT that has an increase rish of uterine cancer but now has progestin to limit endometral hyperplasia
Medroxyprogesterone acetate (MPA)
A SERM that is used to treat B Ca. bc it blocks the estrogen receptor in breast cells.
contridicated in pt with endometral cancer
Tamoxifen
a SERM that treats B. Ca and helps treat osteoprosis also.
2x at risk for DVT and PE
Raloxifene
A drug that blocks all estrogen (weak agonist and strond estrogen antagonist)
It is used for infertility (induction of ovulation)
SE: ovarian cysts and multiple births
Also a drug that does the same but is a complete estrogen agonist
Clomiphene
Fulvestrant
What are 3 types of progesterone that interacts with the PR
it helps establish and maintain a pregnancy
also a oral contraceptive
Prometrium
Crinone
Progestasert
What drug can be used in the first trimester to terminate a pregnancy? It is also a contraceptive.
contraindicated in pt with asthma and vag bleeding
Mifepristone
a first gen contraceptive drug that has to used with ethinyl estradiol to be able to metabolize it
Mestranol
a 2nd gen contraceptive drug that is very common and is a progestin
Norethindrone
a 3rd generation contraceptive drug that is more potent than estranes and is the safest and lowest SE
Desogestrel
what are the 2 drugs that are used in the monophasic formulation of contraceptives. They maintain a fixed level of hormones for 21 days and 7 days of hormone-free pills
Mestranol and Norethindrone
what are the 2 drugs that are used in the Biphasic formulation of contraceptives. They have a lower concentration for 7days and then higher for the next 14 = this limits the exposure to progestin
Ethinyl estradiol and Norethindrone
what are the 2 drugs that are used in the the triphasic formulation of contraceptives. They have fix concentraions of one with three different levels of another
ethinyl estradiol and norethindrone or gonanes
What are three drugs that are contraceptives that are only pregestin!
Good for women smokers
Oral, IM, sub dermal, and IUD
Northindrone
Levonorgestrel
Medroxyprogesterone
An emergency contraceptive but must be taken within 72 hours of intercourse.
It does not harm established pregnancies
Levonorgestrel
What is the combo therapy for contraception that is a 91 day course of pills - only 1 period every three months?
Levonorgestrel and ethinyl estradiol
If you have a hx of emboli, MI, stroke, decreased liver fx, Br Ca. vag bleeding, pregnancy, and smokers over 35 y.o. - you can absolute not take
Contraceptive drugs
What are the two primary androgens that are synthesized from cholesterol
testosterone and dihydrotesterone
What are two testosterone drugs that are used to treat hyopgonadism in adult males.
Histerone and Androgens
What are two androgen receptor antagonist that are used to treat Prostate cancer and hirsutism in women (facial hair)
Flutamide and Bicalutamide
What is a 5-alpha reductase inhibitor (androgen antagonist) that is used to treat benign prostate cancer and male pattern baldness
Finasteride
