Test # 4 anticonvulsants Flashcards
What is the key feature when a patient is having a simple partial (focal) seizure?
preservation of consciousness
What are the three MOA for anti-seizure drugs
- inhibit Na channels to slow neuron firing
- enhancing GABA
- inhibit Ca channels
Name the 3 first line drugs that are Na channels blockers
These drugs inhibit AP firing
Phenytoin
Cabamazepine
Valproic acid
What is a Na channels blocker that is the fist choice for partial and generalized seizures.
drug-drug interaction with warfarin
SE: Gingival hyperplasia, ance, hirsutism
DON’t prescribe in children
Phenytoin
What is another Na channel blocker (inhibits release of glutamate) and can be used in children as adjunct therapy. But may make myoclonic seizure worse
BLACK BOX - aseptic meningitis
Lamotrigine
What is a long acting barbiturate that is used for anticonvulsants but has sedative properties?
Phenobarbital
What anticonvulsant drug ( a Ca channel blocker) would be the first choice for absent seizures? but you can def not give for Tonic clonic seizures!!!!!
Ethosuxoimide
Which is the major MOA for anti-convulsant drugs?
The drugs that inhibit voltage-gated Ca channels
What anticonvulsant drug produces gingival hyperplasia and is first choice for tonic-clonic generalized seizures?
Phenytoin - never use in children
What type of seizure is characterized by lapses of awareness and vacant starring?
absence seizures
What drug enhances the inhibition by using GABA
Phenobarbital
What type of seizure is the only one that can cause death because there are periods of no breathing “blue face”
Status Epilepticus
What drug is preferred to treat status epilepticus because it does not collapse BV like diazepam does
Lorazepam
What anticonvulsant drug ( a Ca channel blocker) is good for adjunct therapy for partial and 2dary generalized sz. Mostly used for Neuropathies (diabetics)
Gabapentin
What anti-convulsant drug is just like Gabapentin but is much more potent! A Ca channel blocker
Pregabalin
