Test #4 Anti-Inflammatory Flashcards

1
Q

What is the rhythm called when you body produces a neg feedback. Once your body produces enough cortisol for the day it starts to decrease until midnight

A

Diurnal rhythm

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2
Q

What are the main MOA of glucocorticoids? (steroids)

A

Increase adrenergic drug activity
Vascular effects
limits damage to spinal cord in trauma

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3
Q

In the Arachidonic acid cascade; glucocorticoids can block _____ this is at the very beginning of the cascade which produces an anti-inflammatory effect.

A

Phospholipase A2 (PLA2)

by blocking this you block the sensitization

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4
Q

What do all Prostaglandins do

A

cause sensitization of the neurons

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5
Q

You can not give glucocorticoids to what type of patients

A

Diabetic patients

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6
Q

What are 3 biological effects of glucocorticoids?

A
  • increase energy by increaseing production of glucose and glycogen
  • bone catabolism - osteoporosis
  • fetal growth - surfactant
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7
Q

What are two SE of the eyes of long term use of steroids?

A

Eyes bulging and cataracts

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8
Q

What disease is caused by an overproduction of glucocorticoids? you have a moon face, buffalo hump and purple striae

A

Cushings

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9
Q

What disease is caused by a deficiency of of glucocorticoids
Primary - adrenal cortex not producing cortisol (surgical removal or pituitary
Secondary - ACTH deficiency

A

Addison’s disease

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10
Q

How do you treat Addison’s disease?

A

Replacement therapy - alternate day therapy - use an intermediate acting (24-36hr) every other day

Prednisone, Triamcinilone, or Methylprednisone

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11
Q

What are two SE of long term use of steroids?

A

infection (d/t immunosuppression) and osteoporosis

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12
Q

Where are glucocorticoids synthesized?

A

In the zona fasciculata of the adrenal cortex

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13
Q

What receptors do steroids exert their effects through to translocate on the nucleus to get to the DNA

A

Cytosolic receptors

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14
Q

What are three effects of Glucocorticoids?

A

Anti-insulin, anti-immune, and anti-inflammatory

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15
Q

Name 2 glucocorticoids that have a plasma t1/2 life of 30mins and a bio t1/2 of 8-12 hrs

Best for mineralocorticoids effects

A

Cortisone and hydrocortisone

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16
Q

Name 3 glucocorticoids that have a plasma t1/2 life of 60-180mins and a bio t1/2 of 18-36 hrs

Best for anti-inflammatory effects

A

Prednisone
Triamcinilone
Methylpresnisone

17
Q

Name 2 glucocorticoids that have a plasma t1/2 life of 100-300mins and a bio t1/2 of 36-54 hrs

Best for anti-inflammatory effects

A

Dexamethasone

Bethamethasone