Teratogens Flashcards
What can teratogens cause
Intrauterine death
Intrauterine growth restriction (IUGR)
Developmental dealy
Strucutal malformations
Physical & mental disability
Carcinogens
How many weeks of pregnancy would teratogens have the most severe impact and why
Weeks 3 -> 11
As this is when organogenesis occurs
After how many weeks of pregnancy would teratogens cause functional and growth defects
>12 weeks
What are the main 4 teratoegens
TORCH
TOxoplasmosis
Rubella
Cytomegalovirus
HSV
Apart from the TORCH infections, give some other examples of teratogens
Thalidomide
Retinoids
Anticonvulsants
Opiates
Alcohol
Parovirus B19
Why would you consult a women of child bearing age who is being treated for acne
If they are planning on becoming preggers
As acne is often treated with retinoids
And retinoids are teratogenic
Carbamazepine, sodium valporate and phenytoin all need to be stopped prior to a women becoming pregnany, why?
As they are all anticonvulsants
What is a classic sign of thalidomide’s teratogenic affects
Tiny arms
What is the triad of teratogenic features due to rubella
Sensorineural deafness
Eye defects
Congenital heart disease
What is the triad of teratogenic features due to retinoids
Microphtalmia (tiny eyes)
Cleft palate
No ears
(yes…no fucking ears)
What is one of the main teratogenic effects of Cytomegalovirus (CMV)
Deafness boyo
