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Reproductive - step > teratogen slam a jam > Flashcards

teratogen slam a jam Flashcards

1
Q

ACE i

A

renal damage

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2
Q

aklylating agents

A

absence of digits

multiple anomalies

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3
Q

aminoglycosides

A

CNVIII toxicity

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4
Q

carbamazepine

A

facial dysmorphism
developmental delay
neural tube defects
phalanx/fingernail dysplasia

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5
Q

diethylstilbesterol

A

vafinal clear cell adenocarcinoma

congenital mulerina/paramesonephric anomales

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6
Q

folate antagonists

A

neural tube defects

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7
Q

isotretinoin

A

multiple seere bith defects

UST HAVE CONTRACEPTIOn

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8
Q

litium

A

ebstien anomaly

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9
Q

methimazole

A

aplasia cutis ongenita

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10
Q

phenytoin

A

fetal hydantoin syndrome: cleft palate, cardiac defects and phalanx/fingernail hypoplasia

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11
Q

tetracyclines

A

discoloured teeth

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12
Q

thalidomide

A

limb defects:
* phocomelia
* micromelia
FLIPPER limbs

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13
Q

valproate

A

inhibition of maternal folate absorption - neural tube defects

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14
Q

warfarin

A

bone deformities
fetal hemorrahge
abortion
ophthalmologic abonromalites

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15
Q

list the teratogens that can cause neural tube defects

A

carbamazepine
folate antagonists
valproate
maternal diabetes

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16
Q

list the teratogens that can cause cardiac defects

A

lithium - ebstein
pheynytoin - cardiac defects
maternal diabetes
vitamin A

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17
Q

list the teratogens that can cause hand deformities

A

alkylating agents - absence of digits
carbamazepine and phenytoin - phalanx/fingernail hypoolasia
thaliomide - phocomelia, micromelia

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18
Q

list the effects of OH as a teratogen

A

common cause od bith defects and inelletula disbaility

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19
Q

cocaine

A

abnormal fetal growth
fetal addiction
placental abruption

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20
Q

smoking

A 
low birth weight - leading cause in developed coutnried
preterm labour
placental problems
IUGR 
ADHD
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21
Q

what is the leading cause of low birth weight in developed country

22
Q

iodine lack or excess

A

congenital goiter or hypothyroidism/cretinism

23
Q

maternal diabetes

A

caudal regression sydnrome – antal atrsia to sirenomelia (mermaid syndrome)
congenital heart defects
neural tube defects

24
Q

vitamin A excess

A

extremely high risk for spontaneous abortions (warfarin also can cause abortion)
birth defects - left palate and cardiac)

25
Q

xrays

A

microcephaly

intellectula disability

26
Q

renal damage

A

ace inhibitors

27
Q

absence of digits

multiple defects

A

alkylating agents

28
Q

CNVIII toxicity

A

aminoglycosides

29
Q

facial dysmorphisms
neural tube defects
phalanx/fingernail hypoplasia
decelopmental delay

A

carbamazepine

30
Q

vaginal celer cell adenocarcinoma

congenital mullerian anomalies

A

diethylstilbestrol

31
Q

neural tube defects only

A

folate antagonists

32
Q

neural tube defects

A

folate antagonists
valproate
corbamazepine
maternal diabetes

33
Q

multiple severe birth defects

A

isotretinion

34
Q

ebstine anomaly

35
Q

aplasia cutis congnita

A

methimazole

36
Q

what is methimazole

A

agranulocytosis

blocks perixodase

37
Q

fetal hydantoin syndrome?

A

cleft palate
cardiac defects
phalanx/fingernail hyoplasia

38
Q

cleft palate

A

pheyntoin

viamin a excess

39
Q

what casues cleft palate
cardiac defects
phlanx/fingernail hypoplasia

A

fetal hydrantoin syndrome

phenytoin

40
Q

discoloured teeth

A

tetracyclines

41
Q

limb defets - phocmelia, micromelia, flipper limbs

A

thalidomide

42
Q

neurla tube defects from inhibiton of maternal folate absorption

43
Q

bone deformities
fetal hemorrhage
abortion
ophthalmoplegic abnormalities

44
Q

abonral fetal growth
fetal addiction
placental abruption

45
Q 
low birth weight
preterm labour
placental problems
IUGR
ADHD
46
Q

congenital goiter or hypothyroidism/creitnism

A

lack or excess of iodine

47
Q

caudal regression syndomre (ana atreisa to sirenomelia
congenital heart defects
neural tube defects

A

maternal diabetes

48
Q

maternal diabetes

A

caudal regression syndrome - anal astresia to sirenomelia
congenital heart defects
neural tube defects

49
Q

extremely hig risk for spotnaneous abortions and birth defects: cleft lip and palate

A

vitamin A excess

50
Q

cleft lip/palate

A 
phenytoin (also cardiac defects and phalnz/fingernail hypoplasia)
vitamin a (high risk of spontaneous abaortions and birth defects)
51
Q

microcephaly

intelletula disabiltiy

Reproductive - step (11 decks)

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