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Pharmacology > TC6-A--Skin Diseases > Flashcards

TC6-A--Skin Diseases Flashcards

1
Q

Tolnaftate

A

Anti-fungal (not useful against Candida)
- inhibits squalene epoxidase (ergosterol)
SE: ???

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2
Q

Fluocinonide

A

TONS of derm stuff
- Steroid –> anti-inflammatory, anti-mitotic
SE: Lots–> HPA axis dysfxn, Cushing’s, skin atrophy, skin redness

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3
Q

NYStatin

A

Candida infections
- disrupts cell membranes (creates pores, binds membranes)
SE: ???

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4
Q

MiconAZOLE

A

Anti-fungal
- inhibits fungal cytochrome p450 (ergosterol)
SE: ???

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5
Q

Isotretinoin

A

Medically-refractory acne
- (same as retinoic acid)
SE: Teratogenic! (preg. test first), dry or itchy skin/mucous membranes

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6
Q

Minoxidil

A

Promotes hair growth
- Relaxes arterial smooth muscle (similar to hydralazine), unclear MOA for hair growth
SE: hypertension (baroreceptor response, Na+/water retention)

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7
Q

FINasteride

A

Promotes hair growth
- 5 alpha-reductase inhibitor
SE: ED, decreased libido, ejaculation disorder
“Finnish alpha males may have fine hair, but everything else falls.”

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8
Q

METROnidazole

A

Rosacea
- Reduces nitro fxnal groups –> ssDNA breaks
SE: Pot. carcinogen (NO to pregnant, nursing); disulfiram rxn w/oral ingestion

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9
Q

BeclomethaSONE

A

TONS of derm stuff
- Steroid –> anti-inflammatory, anti-mitotic
SE: Lots–> HPA axis dysfxn (e.g. cortisol), Cushing’s, skin atrophy, skin redness

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10
Q

Ciclopirox

A

Dermatomycosis (e.g. candidiasis)
- Unclear (maybe acts at fungal cell wall)
SE: pruritis

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11
Q

PenCYCLOVIR

A

HSV 1, 2
- Guanosine analog –> inhibits viral DNA polymerase
SE: ???

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12
Q

Podophyllin

A

Condyloma accuminata
- Inhibits mitotic spindle formation –> inhibits cell division
SE: Teratogen! (Preg. test first), neurologic symptoms

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13
Q

ClindaMYCIN

A

Acne– First line
- blocks 50S subunit
SE: C. diff colitis

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14
Q

Capsaicin

A

Muscle pain, aches
- Desensitizes sensory C fibers
SE: N/V, abdominal pain

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15
Q

Azelaic acid

A

Acne (vulgaris, rosacea)
- Unclear MOA
SE: ???

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16
Q

Oxybenzone

A

Sunscreen

- absorbs 250-360 nm (less effective than PABA)

17
Q

TriamcinolONE

A

TONS of derm stuff
- Steroid –> anti-inflammatory, anti-mitotic
SE: Lots–> HPA axis dysfxn (e.g. cortisol), Cushing’s, skin atrophy, skin redness

18
Q

Terbinafine

A

Anti-fungal (less useful against yeast)
- inhibits squalene epoxidase (ergosterol)
SE: ???

19
Q

LINDAne

A

Pediculus capitus, pediculous pubis
- Blocks GABA
SE: neurotoxin (seizures, hematotoxicity = caution in infants, children, pregnancy)
“LINDA with lice likes to GAB”

20
Q

ErythroMYCIN

A

Acne– First line
- blocks 50S subunit
SE: antibiotic resistance

21
Q

Fluorouracil

A

Actinic keratoses
- Keratolytic agent (inhibits thymidylate synthetase –> disrupts DNA synthesis)
SE: Photosensitivity

22
Q

Retinoic acid

A

Medically-refractory acne
- Increased epithelial cell turnover; increased dermal collagen synthesis, increased angiogenesis, thickened epithelium
SE: Teratogenic! (preg. test first), redness, tumorigenic (if area exposed to UV light)

23
Q

DOXepin

A

Itching (Dog + Fox = DOX but still w/fleas = itch)
- H1, H2 antagonist
SE: Drowsiness, anticholinergic effects

24
Q

ClotrimAZOLE

A

Anti-fungal
- inhibits fungal cytochrome p450 (ergosterol)
SE: ???

25
Q

Salicylic acid

A

Keratosis
- Keratolytic agent
SE: salicylate toxicity, anaphylaxis, erythema multiforme

26
Q

TAZARotene

A

Psoriasis, Acne
- Modifies gene expression via retinoic acid receptor (TARZan swinging on a vine (DNA) with big blue eyes (RETINa = RETINoic acid)
–> anti-inflammatory, anti-proliferative
SE: Teratogenic! (preg. test first), worsened photosensitivity (don’t take tetracyclines), peeling, burning, redness

27
Q

Permethrin

A 
Pediculus humanus (lice), scabies
- Disrupts Na+ channels --> pest paralysis
SE: neurotoxin (slows conduction)
28
Q

Crotamiton

A

Scabies
- Unclear MOA
SE: ???

29
Q

PABA

A

Sunscreen
- absorbs 280-320 nm (UVB rays)
SE: photosensitivity

30
Q

Benzoyl peroxide

A

Acne (vulgaris)– First Line
- Antimicrobial, causes skin peeling, comedolytic
SE: local rxn, bleaches hair

31
Q

Selenium sulfide/Ketoconazole shampoo

A

Seborrhea
- Unclear MOA
SE: ???

32
Q

Propylene glycol

A

Conditions needing moisturization (hyperkeratosis, ichthyosis, psoriasis, lichen planus)
- Keratolytic, hygroscopic agent
SE: ???

33
Q

Psoralen (Sword)

A

Psoriasis, vitiligo
- Photosensitizing drug– makes DNA more susceptible to UVB damage (Stabbing DNA with a sword)
SE: Photoaging, skin CA, melanoma, cataracts

34
Q

HydrocortiSONE

A

TONS of derm stuff
- Steroid –> anti-inflammatory, anti-mitotic
SE: Lots–> HPA axis dysfxn (e.g. cortisol), Cushing’s, skin atrophy, skin redness

35
Q

Mupirocin

A

Topical agent (Staph, Strep infections)

Pharmacology (33 decks)

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