TC5-A GI--Acid & Motility

Question 1

Calcium Carbonate

Answer 1

Antacid
“Tums”
SE: hypercalcemia, calcium stones, chelator effect

Question 2

CimetIDINE

Answer 2

Histamine II receptor antagonist

SE: increased creatinine, pancytopenia, decreased androgens (decreased libido, increased prolactin, gynecomastia)

Question 3

Erythromycin

Answer 3

Macrolide antibiotic/Motilin receptor agonist

SE: diarrhea, prolong QT, inhibit cytochrome P450

Question 4

FamotIDINE

Answer 4

Histamine II receptor agonist

Question 5

SucrALfate

Answer 5

Sugar + AlOH
Forms a protective barrier within the ulcer
SE: aluminum toxicity, constipation, malabsorption syndromes

Question 6

Aluminum Hydroxide

Answer 6

Antacid

SE: constipation, muscle weakness, osteodystrophy

Question 7

OmeprAZOLE

Answer 7

PPI
SE: increased risk of C. diff infection, rebound GERD w/discontinuation, gastric hyperplasia w/chronic use, vitamin/mineral malabsorption w/chronic use

Question 8

Metoclopramide

Answer 8

D2 agonist
SE: increased prolactin (and everything that goes with), drowsiness, extrapyramidal symptoms (acute dystonia, akathisia, bradykinesia, parkinsonisms, tardive dyskinesia)

Question 9

MisoPROSTol

Answer 9

PGE1 analog (rarely used)
SE: stimulates uterine contractions--don't use in pregnant women

Question 10

Bismuth Subsalicylate

Answer 10

Coating agent + salicylate
Tx of ulcers (bismuth), diarrhea (salicylate inh of PG’s), antimicrobial
SE: Reye Syndrome (<18 y/o), subsalicylate toxicity, black tongue/stool, renal insufficiency

Question 11

LansoprAZOLE

Answer 11

PPI
SE: increased risk of C. diff infection, rebound GERD w/discontinuation, gastric hyperplasia w/chronic use, malabsorption syndrome w/chronic use

Question 12

Magnesium Hydroxide

Answer 12

Antacid

SE: diarrhea, hyporeflexia