TC4-F Chemotherapies

Question 1

Doxorubicin

Answer 1

Anti-topoisomerase chemotherapeutic (“anthracycline”–antibiotic)

Question 2

Bleomycin

Answer 2

Anti-topoisomerase chemotherapeutic (DNA-cleaving antibiotic)
- Isolated from Streptococcus verticillus

Question 3

6-Mercaptopurine

Answer 3

Purine analog (chemotherapeutic)

Question 4

Cyclophosphamide

Answer 4

Alkylating chemotherapeutic (nitrogen mustard)

Question 5

IrinoTECan

Answer 5

Anti-topoisomerase I chemotherapeutic

Question 6

Leuprolide

Answer 6

GRH analog (chemotherapeutic)

Question 7

Carmustine

Answer 7

Alkylating chemotherapeutic (nitrosourea)

Question 8

Palbociclib

Answer 8

CDK4, CDK6 inhibiting chemotherapeutic

Question 9

ETOPOside

Answer 9

Anti-topoisomerase II chemotherapeutic (epipodophyllotoxin)

Question 10

Imatinib Mesylate

Answer 10

Monoclonal antibody chemotherapeutic (BCR-ABL, “Gleevec”)

Question 11

Atezolizumab

Answer 11

Monoclonal antibody chemotherapeutic (anti-PD1)

Question 12

Trastuzumab

Answer 12

Monoclonal antibody chemotherapeutic (targeted at ErbB2)

Question 13

Tamoxifen

Answer 13

Competitive inhibitor of estrogen (chemotherapeutic)

Question 14

5-Fluorouracil

Answer 14

Pyrimidine analog (chemotherapeutic)

Question 15

Gemcitabine

Answer 15

Pyrimidine analog (chemotherapeutic)

Question 16

HydRoxyuRea

Answer 16

Ribonucleotide reductase inhibitor (chemotherapeutic)

Question 17

VemuRAFeniB

Answer 17

BRAF inhibiting chemotherapeutic

Question 18

Procarbazine

Answer 18

Alkylating chemotherapeutic

Question 19

Bortezomib

Answer 19

Signal pathway disrupting chemotherapeutic (binds 20S core of 26S proteasome)

Question 20

PacliTAXel

Answer 20

Anti-microtubule chemotherapeutic (taxane, disordered microtubule formation)

Question 21

Mitomycin C

Answer 21

Alkylating chemotherapeutic

- Isolated from Streptococcus caespitosus

Question 22

Trametinib

Answer 22

Steroid hormone antagonist chemotherapeutic

Question 23

Methotrexate

Answer 23

Dihydrofolate reductase inhibitor (chemotherapeutic)

Question 24

Cisplatin

Answer 24

Alkylating chemotherapeutic (Pt-coordination complex)

Question 25

L-asparaginase

Answer 25

Asparagine hydrolyzer (chemotherapeutic)

Question 26

Letrozole

Answer 26

Aromatase inhibitor (chemotherapeutic)

Question 27

ICI183780, “Fulvestrant”

Answer 27

Pure estrogen antagonist (chemotherapeutic)

Question 28

Vincristine

Answer 28

Anti-microtubule chemotherapeutic (binds tubulin)