TC5-H--Herpes, CMV, Influenza

Question 1

AcyCLOVIR

Answer 1

Guanosine analog (inhibits viral DNA/RNA synthesis)
Tx: HSV, VZV
SE: Obstructive crystalline nephropathy, acute renal failure

Question 2

ValacyCLOVIR

Answer 2

Guanosine analog (inhibits viral DNA/RNA synthesis)
Tx: HSV, VZV
SE: Obstructive crystalline nephropathy, acute renal failure

Question 3

GanciCLOVIR

Answer 3

Guanosine analog (inhibits viral DNA/RNA synthesis)
Tx: CMV
SE: Myelosuppression, nephrotoxicity

Question 4

ValganciCLOVIR

Answer 4

Guanosine analog (inhibits viral DNA/RNA synthesis)
Tx: CMV
SE: Myelosuppression, nephrotoxicity

Question 5

Foscarnet

Answer 5

PPi analog (inhibits DNA-pol, HIV R-transcriptase)
Tx: Acyclovir-resistant HSV, ganciclovir-resistant CMV
SE: nephrotoxicity, seizures, hypomagnesemia, hypocalcemia, hepatitis, thrombophlebitis, genital ulcers, anemia, leukopenia, hepatitis, ECG changes, hallucinations

Question 6

OseltamiVIR

Answer 6

Neuraminidase inhibitor
Tx: Influenza A and B
SE: GI upset

Question 7

ZanamiVIR

Answer 7

Neuraminidase inhibitor
Tx: Influenza A and B
SE: bronchospasm

Question 8

AmantadINE

Answer 8

M2 proton channel inhibitor
Tx: Influenza A
SE: CNS and GI symptoms
*NOTE: crosses BBB

Question 9

RimantadINE

Answer 9

M2 proton channel inhibitor
Tx: Influenza A
SE: CNS and GI symptoms (less severe than amantadine)
*NOTE: does not cross BBB

Question 10

Lamivudine

Answer 10

Nucleoside RT inhibitor (cytosine)
Tx: HBV
SE: URI, hepatomegaly with steatosis, lactic acidosis, ↑CK, myalgia/myopathy

Question 11

IFN-alpha

Answer 11

Immune modulator (induces apoptosis, inhibits viral replication)
Tx: HCV, chronic HBV
SE: Fever, fatigue, rash, URI, transaminitis, otitis
media

Question 12

RibaVIRIN

Answer 12

Guanosine analog (inhibits viral RNAP, mRNA capping)
Tx: HCV
SE: Teratogen, dose-dependent hemolytic anemia, rash,
pruritis, cough