TC3-A NSAID's

Question 1

AcetaminophEN

Answer 1

Nonselective COX inhibitor (not anti-inflammatory)

- Hard on the liver, kidney

Question 2

AspirIN

Answer 2

IRREVERSIBLE Nonselective COX inhibitor (platelets)

• Cardioprotective
• Reye’s syndrome (SE), don’t give to pt’s with bleeding problems

Question 3

DicloFENac

Answer 3

Nonselective COX inhibitor

- Ophthalmic anti-inflammatory, topical gel

Question 4

IbuproFEN

Answer 4

Nonselective COX inhibitor

• Closure of PDA
• May limit cardioprotective effect of aspirin when taken in conjunction

Question 5

IndomethacIN

Answer 5

Nonselective COX inhibitor

• Closure of PDA, ophthalmic anti-inflammatory, gingival anti-inflammatory
• Risk of pancreatitis

Question 6

KetoproFEN

Answer 6

Nonselective COX and LOX inhibitor

Question 7

NaprOXEN

Answer 7

Nonselective COX inhibitor

- Rheumatic dz

Question 8

Nabumetone

Answer 8

Naproxen pro-drug

- Long half-life, very expensive

Question 9

PirOXicam

Answer 9

Nonselective COX inhibitor

- Long half-life–> 1x/day dosing

Question 10

CelecOXib

Answer 10

Selective COX-2 inhibitor

• no cardioprotective effects
• same renal problems, less GI problems, some rashes

Question 11

KetorolAC

Answer 11

Nonselective COX inhibitor

- Short-term analgesic (IV)–used instead of morphine

Question 12

PrednisONE

Answer 12

Steroid (inhibits phospholipase A2)

Question 13

SulindAC

Answer 13

Sulfoxide pro-drug– nonselective COX inhibitor

• Rheumatic dz, familial intestinal dz
• Stevens-Johnson epidermal necrolysis, agranulocytosis, thrombocytopenia