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Pharmacology > TC4-D Toxicology > Flashcards

TC4-D Toxicology Flashcards

1
Q

Hydroxocobalamin

A
  • Treatment of CN toxicity - Generates CoCN
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2
Q

EDTA

A

Chelating agent (give only as calcium disodium salt) - Treatment of lead, zinc, manganese, heavy radionucleotide (e.g. plutonium, americium, curium) toxicity SE: lowered zinc

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3
Q

Sodium Thiosulfate

A
  • Treatment of CN toxicity - Generates Thiocyanate
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4
Q

DeFERoxamine

A

Chelating agent (binds to iron on iron-transport proteins) - Treatment of iron, aluminum toxicity SE: hypotension (rapid infusion), flushing, abdominal discomfort

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5
Q

DiMERCaprol

A

Chelating agent (single use) - Treatment of acute arsenic, inorganic mercury toxicity - Combined w/EDTA to treat severe lead toxicity

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6
Q

Fomepizole

A

Alcohol dehydrogenase competitive antagonist - Treatment of ethylene glycol and methanol toxicity

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7
Q

Nitrites

A
  • Treatment of CN toxicity - Generates CNMetHb
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8
Q

Pralidoxime

A

ACHE binder (binding knocks off organophosphate) - Treatment of organophosphate toxicity

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9
Q

METhylene Blue

A

Oxidizing agent - Treatment of methemoglobinemia

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10
Q

Penicillamine

A

Chelating agent (water-soluble derivative of penicillin) - Treatment of copper toxicity SE: hypersensitivity rxns; don’t give to pt’s w/penicillin allergy; prolonged use– nephrotoxicity, pancytopenia

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11
Q

ACETylcysteine

A

MOA? - Treatment of acetaminophen (tylenol) overdose

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12
Q

Sodium Bicarbonate

A

Weak base - Treatment of salicylate toxicity

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13
Q

Naloxone

A

Mu receptor competitive antagonist - Treatment of opioid toxicity

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14
Q

Atropine

A

Muscarinic antagonist - Treatment of organophosphate toxicity

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15
Q

Succimer

A

Chelating agent (water-soluble analog of dimercaprol) - Treatment of lead, mercury, arsenic toxicity SE: GI disturbances, neutropenia

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16
Q

FlumAZeNIL

A

GABA competitive antagonist - Treatment of benzodiazepine toxicity

17
Q

Physostigmine

A

AChE inhibitor - Treatment of anti-cholinergic (anti-muscarinic) toxicity

Pharmacology (33 decks)

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