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1
Q

18.
A patient is admitted to the hospital because of a bleeding duodenal ulcer.
Culture at 37.0 C (98.6 F) reveals a urease-positive, gram-negative, curved rod. Which of the following is a likely complication due to infection with the causal agent?
A. Diarrhea
B. Kidney stones
Pseudomembranous colitis
D.
Stomach cancer
E. Vomiting

A

Stomach cancer

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2
Q
  1. A 30-year-old man presents to his physician with complaints of mid-epigastric pain. He describes the pain as moderate, occasionally waking him at night, and improving immediately following meals. A urease breath test was positive. Which of the following correctly describes the causal agent?
    A. Gram-negative curved rod; microaerophilic
    B. Gram-negative rod; aerobic
    C. Gram-negative rod; facultative anaerobe
    D. Gram-positive rod; aerobic
    E. Gram-positive rod; microaerophilic
A

A. Gram-negative curved rod; microaerophilic

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3
Q
  1. Which of the following conditions is not alarm symptoms in patients with P ulcer disease?
    A. Unintentional weight loss
    B. Progressive dysphagia
    C. Nausea and vomiting
    D. Recurrent and overt gastrointestinal bleeding
    E. Iron deficiency anemia
A

C. Nausea and vomiting

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4
Q
  1. Which of the following is the most common type of peptic ulcer?
    A. Duodenal ulcers
    B. Gastric (stomach) ulcers
    C. Marginal ulcers
    D. Stress ulcers
    E. Curling ulcers
A

A. Duodenal ulcers

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5
Q
  1. Which of the following is not a complication of P ulcer disease?
    A. Upper gastrointestinal bleeding
    B. Gastric outlet obstruction
    C. Perforation
    D. Hematuria
    E. Penetration
A

D. Hematuria

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6
Q
  1. In addition to Helicobacter pylori infection of the stomach, what is the most common cause of peptic ulcer?

Use of nonsteroidal anti-inflammatory drugs (NSAIDs)
B. Steroids
C. Smoking
D. Alcohol
E. Stress

A

Use of nonsteroidal anti-inflammatory drugs (NSAIDs)

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7
Q
  1. Which of the following is a small molecule that polymerizes in stomach acid and coats the ulcer bed, resulting in accelerated healing and reduction of symptoms?
    A. Aluminum hydroxide
    B. Metoclopramide
    C. Sucralfate
    D. Dexamethasone
    E. Misoprostol
A

C. Sucralfate

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8
Q
  1. Which of the following pharmacodynamics and pharmacokinetic properties of proton pump inhibitors is wrong?
    A. They are lipophilic weak bases
    B. They diffuse into parietal cell canaliculi
    C. Duration of action is 24 hours
    D. Reversibly inactivate the parietal cell H/ K ATPase
    E. After absorption in intestine rapidly metabolized in liver (tin: 1-2 h)
A

D. Reversibly inactivate the parietal cell H/ K ATPase

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9
Q
  1. Which is the direct cause of increased acid secretion in peptic ulcer?
    A. H.pylori
    B. Local vasodilation
    C. Increased capillary permeability
    D. Formation & liberation of histamine
    E. Stimulation of cholinergic intramural plexus
A

D

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10
Q
  1. Which of the below choices is not associated with peptic ulcer disease?
    A. Helicobacter pylori infection
    B. Alcohol ingestion
    C. Type A blood type
    D. Psychological stress
    E. Smoking
A

C. Type A blood type

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11
Q

Which is the most common area for autoimmune gastritis?
A. Proximal duodenum
B. Gastro-esophageal junction
C. Gastric cardia
D. Ileum
Gastric body

A

Gastric body

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12
Q
  1. Which one of the below choices is not a complication of chronic gastritis?
    A. Peptic ulcer disease
    B. Squamous metaplasia
    C. Mucosal atrophy
    D. Intestinal metaplasia
    E. Dysplasia
A

B. Squamous metaplasia

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13
Q
  1. Which of the following is wrong about the comparison between gastric & duodena
    ulcers?
    A. Serum pepsinogen level is increased in duodenal ulcer not in ulcer gastric
    B. Associated gastritis is seen in both forms
    C. Age of onset is higher in gastric ulcer compared to duodenal
    D. Abnormal mucus is seen in both types
    E. Serum gastrin level is increased in gastric ulcer not in duodenal ulcer
A

B. Associated gastritis is seen in both forms

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14
Q

Which of the following drug group is used for acid peptic disease?
A. Corticosteroids
B. Anti-histaminic (H1 blockers) drugs
C. Laxatives
D. Proton pomp inhibitors
E. 5HT3 blockers

A

D. Proton pomp inhibitors

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15
Q
  1. Which of the following is not a H2- receptor antagonist
    A. Ranitidine
    B. Cimetidine.
    C. Famotidine
    D. Nizatidine
    Ampicilline
A

Ampicilline

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16
Q
  1. Which of the following statements about cimetidine is wrong?
    A. Not used for the treatment of gastrosophageal reflux disease
    B. Available as oral and intravenous route
    C. Side effects include gynecomastia and galactorrhea
    D. Inhibits several cytochrome P450 isoenzymes
    E. Interfere with the metabolism of many drugs
A

A. Not used for the treatment of gastrosophageal reflux disease

17
Q
  1. Which of the following is an analog of PGE1 that protects mucosa?
    Colloidal bismuth
    B. Misoprostol
    C. Sucralfate
    D. Metoclopramide
    E. Ondansetron
A

B. Misoprostol

18
Q
  1. What is the first morphologic change in gastritis?
    A. Macosal injury
    B. Plasma cell groups in lamina propria
    C. Shallow ulcers
    D. Reactive lymphoid hyperplasia
    E. Hemorrhage
A

A

19
Q
  1. Which of the below choices is not a protective mechanism against mucosal injury in stomach?
    A. Mucin secreted by foveolar cells
    B. Presence of bicarbonate ions in mucin secreted by surface cells
    C. The rich blood supply to the mucosa
    D. Prèsence of serosal surface
    E. Neutral pH of mucin
A

D