TB Drugs Flashcards
which drugs are mycolic acid synthesis inhibitors (what line are they)
- isoniazid (first line)
- dalamanid (second line)
- pretomanid (second line)
what drugs are cell wall synthesis inhibitors (what line are they)
- ethambutol (first line)
- cycloserine (second line)
what drugs are RNA polymerase inhibitors (what line)
- rifampin (first line)
- rifabutin (first line)
what drugs are protein synthesis inhibitors (what line)
aminoglycosides
- streptomycin (second line)
- amikacin (second line)
- kanamycin (second line)
what drugs are DNA synthesis inhibitors (what line)
- levofloxacin (second line)
- moxifloxacin (second line)
what drugs are ATP synthase inhibits (what line)
- bedaquiline (second line)
intensive phase uses which drugs
how long is intensive phase
- all 4 front line drugs
- H+R+Z+E
- 8 weeks
continuation phase uses which drugs
how long is continuation phase
- H+R
- 18 weeks
what drugs are effective against latent TB
- rifampin (also effective against active)
- rifabutin (also effective against active)
- pyrazinamide
isoniazid bacterial enzymes needed to convert it to active form
- KatG
what bacterial enzyme does isoniazid inhibit
result
- InhA
- prevents mycolic acid precursor from turning into mycolic acid
mutations in ______ and ______ confer resistance to isoniazid
- KatG
- InhA
isoniazid toxicities
- hepatotoxicity
- peripheral neuropathy
INH - INJURY TO NERVES AND HEPATOCYTES
how does isoniazid cause toxicities
- intermediate compounds produce toxic reactive metabolites which cause liver damage
which acetylators of isoniazid are less prone to toxicity
- fast acetylation
