Respiratory Immunology Refresher Flashcards
1
Q
what is the cleansing mechanism
A
- a layer of mucus flows toward the pharynx for expectoration or swallowing
2
Q
mucus clearance is aided by
A
- coordinated secretion of mucins and proteins
- sufficient water for hydration
- beating cilia
- sneezing and coughing
3
Q
protective antimicrobial factors
A
- antioxidants
- defensins
- lactoferrins
- lysozyme
4
Q
what immune cells are the first line of defense
A
- structural
- sentinel
- innate lymphocyte
5
Q
example of structural cells
A
- epithelial
6
Q
example of sentinel cells
A
- tissue and alveolar macrophages
7
Q
example of innate lymphocyte cells
A
- NK cells
8
Q
what is the most common serious life limiting genetic disease of caucasians
A
- cystic fibrosis
9
Q
genetics of cystic fibrosis
A
- autosomal recessive
10
Q
gene mutated in cystic fibrosis
A
- CFTR apical membrane Cl- channel
11
Q
median survival of cystic fibrosis
A
- around 40 years
