Bacterial Drug Guide Broken Down Flashcards
MOA of sulfonamides
- folate synthesis inhibitors
sulfonamide drug to know
which are anti-pseudomonals
- sulfamethoxazole
what drug do we combine sulfamethoxazole with
- trimethoprim
MOA of flouroquinolones
- DNA damaging
- inhibit DNA gyrase
fluoroquinolone drugs to know
which are anti-pseudomonals
- ciprofloxacin (anti-pseudomonals)
- levofloxacin (anti-pseudomonals)
- moxifloxacin
- gemifloxacin
what are the two classes of cell wall synthesis inhibitors
- beta lactams
- glycopeptides
what are the drug classes in the beta lactam class?
- penicillins
- monobactams
- carbapenems
- cephalosporins
MPCC Beta lactam
broad spectrum penicillins to know
which are anti-pseudomonals
- ampicillin
- amoxicillin
- piperacillin (anti-pseudomonals)
monobactam drugs to know
which are anti-pseudomonals
- aztreonam (anti-pseudomonals)
carbapenem drugs to know
which are anti-pseudomonals
- imipenum (anti-pseudomonals)
- meropenum (anti-pseudomonals)
cephalosporin drugs to know
which are anti-pseudomonals
- cefuroxime
- ceftriaxone
- cefotaxime
- cefpodoxime
- ceftazidime (anti-pseudomonals)
- cefepime (anti-pseudomonals)
- ceftaroline
what drugs to combine with lactamase inhibitors?
- monobactams
- carbapenems
lactamase inhibitors to know
which are anti-pseudomonals
- clavulanic acid
- tazobactam
glycopeptides to know
which are anti-pseudomonals
- vancomycin
what drug classes are protein synthesis inhibitors?
- 30S
- 50S
what drug classes are 30S protein synthesis inhibitors?
- aminoglycosides
- tetracyclines
AT 30
what drug classes are 50S protein synthesis inhibitors?
- macrolides
- oxazolidenones
- streptogramins
- lincosamides
50 is not SMOL
aminoglycoside drugs to know
which are anti-pseudomonals
- gentamycin (anti-pseudomonals)
- tobramycin (anti-pseudomonals)
- amikacin (anti-pseudomonals)
tetracycline drugs to know
which are anti-pseudomonals
- doxycycline
macrolide drugs to know
which are anti-pseudomonals
- erythromycin
- clarithromycin
- azithromycin
MACRO ACE
macrolides are pretty much effective against all gram positive except for which organism?
- H. flu
oxazolidenone drugs to know
which are anti-pseudomonals
- linezolid
lincosamide drugs to know
which are anti-pseudomonals
- clindamycin
cell membrane disruptor classes of drugs
- polymyxin B
- daptomycin
polymyxin B drugs to know
which are anti-pseudomonals
- polymyxin E (colistin) (anti-pseudomonals)
all folate synthesis inhibitors work against which organism class (gram+ or gram-)
- both
all fluoroquinolones work against which organism class (gram+ or gram-)
- both
all broad spectrum penicillins work against which organism class (gram+ or gram-)
- both
all monobactams work against which organism class (gram+ or gram-)
- gram negative
all carbapenems work against which organism class (gram+ or gram-)
- both
most cephalosporins work against which organism class (gram+ or gram-)
except which one (and what does it work against)
- both
- ceftazidime (gram negatives)
all glycopeptides work against which organism class (gram+ or gram-)
- gram negatives
all aminoglycosides work against which organism class (gram+ or gram-)
- both
all tetracyclines work against which organism class (gram+ or gram-)
- both
all macrolides work against which organism class (gram+ or gram-)
except which organism in particular
- gram positive
- gram negative H. flu
all oxazolidenones work against which organism class (gram+ or gram-)
- gram positives
all lincosamides work against which organism class (gram+ or gram-)
- both
all polyxmin B’s work against which organism class (gram+ or gram-)
- gram negative
