TB

Question 1

Positive TST, CXR negative

Answer 1

Reduce the risk of developing ACTIVE TB

• Isoniazide (INH) 300mg QD x 9 MONTHS
  - Add Vit B6 (Pyridoxine) 50mg qd
  - HEPATOTOXIC

ALT- Rifampin 600mg QD x4 months

OR

Isoniazid 900mg + rifapentin 900mg WEEKLY x 12 weeks

Question 2

INH

Answer 2

Isoniazid (INH)

-Hepatotoxic (MONITOR LFT’s)
(Report: fatigue; n/v; dark urine

DI: theophylline; warfarin; phnytoin
( 1A2; 2C9 inhibitor)

Peripheral Neuropathy which is WHY PYRIDOXINE (vit b6) is given

Dose: 300mg PO qd

Question 3

Rifampin

Answer 3

• HEPATOTOXIC
• RED/ORANGE discoloration of URINE
• Fever; rash; Flu-like illness, and GI upset
• Thrombocytopenia (CBC): INCREASE BLEEDING

— Rifampin is an INDUCER

• DECREASE LEVELS OF
  1) ORAL CONTRACEPTIVES
  2) INR W/ Warfarin
  3) avoid PROTEASE INHIBITORS

Administer on an EMPTY STOMACHE; decrease levels when taken w/ FOOD

Question 4

Priftin

Answer 4

Rifapentine

LONG acting derivative of RIFAMPIN

• SE: same as rifampin

Question 5

Pyrazinamide

Answer 5

Hepatooxicity

HYPERURICEMIA

Avoid in renal dysfunction

Question 6

Ethambutol

Answer 6

OPTIC NEURITIS check the EYES

CAUTION IN RENAL DISEASE

INCREASE IN URIC ACID

Question 7

Streptomycin

Answer 7

• Nephrotoxicity
• Ototoxicity

Monitor

1) auditory
2) Renal fnx
3) Electrolytes

Question 8

Sirturo

Answer 8

Bedaquiline

Patient FAILED OTHER AGENTS

• Direct OBSERVED THERAPY

Question 9

Rifamate

Answer 9

Isoniazid + rifampin

EMPTY STOMACHE

Question 10

Rifater

Answer 10

Isoniazid + rifampin + pyrazinamide

QD on EMPTY STOMACHE

Question 11

Preferred Regimen to treat TB

Answer 11

• First EIGHT WEEKS (2 MONTHS)
  1) Isoniazid
  2) Rifampin
  3) Pyrazinamide
  4) Ethambutol

Then for 18 WEEKS (4.5 MO)
1) isoniazid and rifampin