taxol

Question 1

taxol fights what type of cancer?

Answer 1

breast cancer

Question 2

taxol is from the bark of _______ and present in ___ concentrations

Answer 2

pacific yew tree
low

Question 3

ratio of bark to taxol concentration

Answer 3

300,000 : 25

Question 4

in order to retrieve taxol from tree, what do you do to each tree and how many trees per patient?

Answer 4

kill tree
3 trees per pacient

Question 5

synthesis is ____ with many ____ centers

Answer 5

complex
chiral

Question 6

is the retrieval of taxol efficient?

Answer 6

NO very inefficient bc not a lot present in a tree so need to synthesize it ourselves

Question 7

taxol is a ___ - terpenoid

Answer 7

DI-terpenoid

Question 8

taxol acts on _____, which affects ______ and the _______

Answer 8

microtubules
mitosis and cytoskeleton

Question 9

taxol ______ microtubules so that they cannot ________.

what does this mean for cell division?

Answer 9

stabilizes
polymerize and depolymerize

microtubules cannot pull spindle fibres apart during division so no cell division occurs

Question 10

______ is a similar to taxol but causes _____

Answer 10

colchicine
microtubule disassembly

Question 11

T/F: taxol and colchicine used to study and treat cancer?

Answer 11

F: both used to study cancer, but ONLY TAXOL TREATS CANCER

Question 12

mechanism of taxol vs colchicine

Answer 12

taxol = microtubules to stable
colchicine = microtubules fall apart

both cause no mitosis

Question 13

how we synthesize can taxol

Answer 13

use fungus from inner bark of pacific yew

Question 14

tree bark fungus makes taxol. explain differences in taxol production between dark and light enviornments

Answer 14

darkness = taxol produced

in presence of light: enzyme creates other pigments, HMGR, DHQ genes blocked, also more stress on fungi

Question 15

explain symbiosis between fungi that makes taxol and tree

Answer 15

benefit to tree = fungi makes antibiotics

fungi = lives