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ANAT2008 > Target Selection and Topographic Maps > Flashcards

Target Selection and Topographic Maps Flashcards

1
Q

What type of muscles do medial MNs innervate?

A

Axial

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2
Q

What type of muscles do lateral MNs innervate?

A

Distal

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3
Q

What type of receptor is Eph?

A

Tyrosine kinase

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4
Q

Where does FGFR1 guide axons?

A

To axial muscle

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5
Q

Where does EphB1 guide axons?

A

To ventral limb mesenchyme

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6
Q

Where does EphA4 guide axons?

A

To dorsal limb mesenchyme

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7
Q

Which receptor does EphrinB bind to?

A

EphB1

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8
Q

What is the concentration gradient of EphrinB and what is its effect?

A

High dorsally, low ventrally

Repels axons to ventral side of limb

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9
Q

Which receptor does EphrinA bind to?

A

EphA4

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10
Q

What is the concentration gradient of EphrinA and what is its effect?

A

High ventrally, low dorsally

Repels axons to dorsal side of limb

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11
Q

What is the effect of attractive cues?

A

Actin assembly and microtubule stabilisation on ipsilateral side

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12
Q

What is the effect of repulsive cues?

A

Actin assembly and microtubule stabilisation on contralateral side

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13
Q

Which molecules regulate the cytoskeleton?

A

Rho family GTPases

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14
Q

Name 3 Rho family GTPases and describe their effects

A

Cdc4 - lamellipodia and filopodia - growth cone extension
Rac - filopodia - growth cone extension
Rho - stress fibres - growth cone retraction

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15
Q

What are the key features of topographic maps?

A

Neighbouring cells in one area connected to neighbouring cells in another area
Order of neurons maintained

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16
Q

What are the key features of discrete maps?

A

Cells expressing same receptor type map to same place - glomeruli

17
Q

Which parts of the retina and tectum are connected by axons?

A

Temporal retina to rostral tectum - nasal retina to caudal tectum
Posterior retina to anterior tectum - anterior retina to posterior tectum

18
Q

Describe Sperry’s experiment

A

Rotated frog eye before axon growth

Axons still went to correct part of tectum - respond to cues in tectum

19
Q

What is the ephA gradient in the retina?

A

High temporally, low nasally

20
Q

What is the ephrinA gradient in the tectum?

A

High caudally, low rostrally

21
Q

What is the ephB gradient in the retina?

A

High ventrally, low dorsally

22
Q

What is the ephrinB gradient in the tectum?

A

High medially, low laterally

ANAT2008 (18 decks)

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