Neurogenesis and Gliogenesis Flashcards
What causes the apico-basal polarity of the neuroepithelial cells in the neural tube?
Interkinetic nuclear migration
What are the two types of neuroepithelial cell division?
Symmetric
Asymmetric
What are the products of symmetric neuroepithelial cell division?
2 neuroepithelial cells / 2 neuroblasts
What are the products of asymmetric neuroepithelial cell division?
Neuroepithelial cell and neuroblast
What are the two phases of neurogenesis?
Expansion phase
Neurogenic phase
What does the expansion phase of neurogenesis involve?
Symmetric neuroepithelial cell divisions - forms many neuroepithelial cells
What does the neurogenic phase of neurogenesis involve?
Asymmetric neuroepithelial cell divisions start - forms lineage-restricted neuroblasts
Eventually symmetric neuroepithelial cell divisions - form 2 neuroblasts
Name the proneural genes
Achaete
Scute
Which process determines the cell that becomes a neuroblast within a proneural cluster?
Lateral inhibition
What is Delta?
Ligand
What is Notch?
Receptor
What is the effect of the mib zebrafish mutant?
Decreased Notch signalling - less lateral inhibition - too many cells express proneural genes - too many neuroblasts form
What is the effect of injecting Notch mRNA into wildtype zerbrafish?
Too few neuroblasts form
What is formed by asymmetric cell division after spindle rotation in Drosophila?
Ganglion mother cell and neuroblast
Is division orientation important in vertebrate neuroblast differentiation?
No
