Tacrolimus DI Flashcards
Tacrolimus drug class
Calcineurin inhibitors
Tacrolimus MoA
Blocks activation and prevents transcription factor in T cells to halt Signal 1
Tacrolimus immediate release products
Prograf, generics
Are Prograf and tacrolimus generics interchangeable?
NO! DAW ON RX!
Can tacrolimus generics be interchanged?
NO! Keep the same manufacturer when possible
Tacrolimus extended-release products
Astagraf XL, Envarsus, IV Prograf
Dose conversion of Astagraf XL to an IR formulation (if you must)
1 mg Astagraf: 1 mg IR
What should you monitor when switching formulations/brands?
Trough concentrations
Is Astagraf interchangeable with IR?
NO!
Trough levels may be ? in Astagraf compared to IR formulations of tacrolimus.
Lower
Envarsus dose conversion
70% of IR dose
Is Envarsus interchangeable with Astagraf or IR formulations?
NOPE!
IV Prograf stability
24 hours
IV Prograf length of administration
24-hour continuous infusion
IV Prograf storage conditions
Glass or polyethylene container
