Interferons-Alfa DI

Question 1

Actions of interferons-alfa

Answer 1

Antiviral effect

Growth inhibitors effect on normal and malignant cells

Question 2

Immunomodulation of interferons-alfa

Answer 2

Enhance NK cell activity
Enhance cytotoxicity of T-cells
Phagocytosis of macrophages

Question 3

Interferons-alfa drugs

Answer 3

Peginterferon Alfa-2a (Pegasys), Peginterferon Alfa-2b (Pegintron)

Question 4

Peginterferon Alfa-2a brand name

Answer 4

Pegasys

Question 5

Peginterferon Alfa-2b brand name

Answer 5

Pegintron

Question 6

What does the pegylated moiety do?

Answer 6

Improve PK, reduces dosing frequency, reduces adverse effects, and increases sustained viral response

Question 7

MoA of interferons-alfa drugs

Answer 7

Induces innate antiviral immune response and inhibits viral replication of virus-infected cells
Suppresses cell cycle progression and proliferation
Induces apoptosis and anti-angiogenic actions

Question 8

Indications of interferons-alfa

Answer 8

Hepatitis C

Question 9

Peginterferon BETA-1a is indicated for what?

Answer 9

Relapsing MS

Question 10

ADEs of interferons-alfa

Answer 10

Bone pain, myalgias, fatigue, fever, HAQ, neutropenia, specific disease response parameters