GM-CSF DI

Question 1

What do GM-CSFs do?

Answer 1

Promote leukopoiesis (WBC production)

Question 2

GM-CSF drug

Answer 2

Sargramostim (Leukine)

Question 3

Sargramostim brand name

Answer 3

Leukine

Question 4

Sargramostim/Leukine MoA

Answer 4

Promotes neutrophil and monocyte production (dose-dependent increase)

Question 5

Indications for sargramostim/Leukine

Answer 5

Myelosuppressive chemo used in bone transplant transplantation, myelodysplastic syndromes, HIV, chemo-induced neutropenia

Question 6

Sargramostim/Leukine ADEs

Answer 6

Fever, diarrhea, N/V, malaise, weakness, headache and chills, rash