Epoetin DI

Question 1

What stimulates erythropoietin synthesis?

Answer 1

Hypoxia

Question 2

Where is erythropoietin synthesized?

Answer 2

Primarily in the kidneys

Question 3

Is epo an endogenous or exogenous CSF?

Answer 3

Endogenous

Question 4

What does epo do after it binds to its receptor?

Answer 4

Promotes proliferation, differentiation, and survival of the erythroid progenitors

Question 5

Erythropoiesis-Stimulating Agents (ESA) MoA

Answer 5

Act similarly to endogenous eco and stimulates erythroid progenitors to differentiate and mature into RBCs

Question 6

ESA drugs

Answer 6

Epoetin-Alfa (Procrit) and Darbepoetin-Alfa (Aranesp)

Question 7

MoA of ESA drugs

Answer 7

Stimulate BFU-E and CFU-E in bone marrow to proliferate and differentiate to mature RBCs and increase oxygen capacity

Question 8

What happens to oxygen capacity when more reticulocytes are produced and released into the blood?

Answer 8

The oxygen capacity increases

Question 9

Epoetin-Alfa brand name

Answer 9

Procrit

Question 10

Darbepoetin-Alfa brand name

Answer 10

Aranesp

Question 11

Indication for ESAs

Answer 11

Anemia from Stage 4 CKD and ESRD
Zidovudine-treated HIV
Chemo-associated anemia

Question 12

ADEs of ESAs

Answer 12

HTN, fever, N/V, headache, rash, itching, joint aches, cough